您当前所在的位置:首页 > 产品中心 > 产品信息
Gallamine Triethiodide_分子结构_CAS_65-29-2)
点击图片或这里关闭

Gallamine Triethiodide

产品号 DB00483 公司名称 DrugBank
CAS号 65-29-2 公司网站 http://www.ualberta.ca/
分子式 C24H45N3O3 电 话 (780) 492-3111
分子量 423.6324 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 366

产品价格信息

请登录

产品别名

标题
Gallamine Triethiodide
IUPAC标准名
(2-{2,3-bis[2-(diethylamino)ethoxy]phenoxy}ethyl)diethylamine
IUPAC传统名
gallamine triethiodide
商标名
Tricuran
Remyolan
Fourneau 2559
Gallaflex
Miowas G
Pyrolaxon
Retensin
Syncurarine
Flacedil
Flaxedil
Parexyl
Pirolakson
Relaxan
Sincurarine
别名
Gallamine Triethiiodide
Gallamin
Benzkurin
Gallamin Triethiodide
Gallamine
Gallamine Triiodoethylate
Gallamone Triethiodide
Triiodoethylate de Gallamine
Gallamine Iodide
Gallamonum
Benzcurine Iodide

产品登记号

CAS号 65-29-2

产品性质

疏水性(logP) 3.5
溶解度 Soluble

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description A synthetic nondepolarizing blocking drug. The actions of gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. It should be used cautiously in patients at risk from increased heart rate but may be preferred for patients with bradycardia. (From AMA Drug Evaluations Annual, 1992, p198)
Indication For use as adjuncts to anesthesia to induce skeletal muscle relaxation and to facilitate the management of patients undergoing mechanical ventilation
Pharmacology Gallamine Triethiodide is a nondepolarizing neuromuscular blocking drug (NDMRD) used as an adjunct to anesthesia to induce skeletal muscle relaxation. The actions of gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. Muscle groups differ in their sensitivity to these types of relaxants with ocular muscles (controlling eyelids) being most sensitive, followed by the muscles of the neck, jaw, limbs and then abdomen. The diaphragm is the least sensitive muscle to NDMRDs. Although the nondepolarizing neuromuscular blocking drugs do not have the same adverse effects as succinylcholine, their onset of action is slower. They also have a longer duration of action, making them more suitable for maintaining neuromuscular relaxation during major surgical procedures.
Affected Organisms
Humans and other mammals
External Links
Wikipedia

参考文献