Anisomycin from Streptomyces griseolus

• 产品号: 10522
• CAS号: 22862-76-6
• 分子式: C14H19NO4
• 分子量: 265.30496
• 纯 度: ≥96.0% (TLC)

产品别名

• 标题: Anisomycin from Streptomyces griseolus
• IUPAC标准名: (2R,3S,4S)-4-hydroxy-2-[(4-methoxyphenyl)methyl]pyrrolidin-3-yl acetate
• IUPAC传统名: anisomycin
• 别名: (2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate; 2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate; Flagecidin

产品登记号

• EC号: 245-269-7
• MDL号: MFCD00077650
• Beilstein号: 20705
• CAS号: 22862-76-6

产品性质

• Empirical Formula (Hill Notation): C14H19NO4
• 纯度: ≥96.0% (TLC)
• 溶解度: methanol: soluble20 mg/mL, clear, colorless to faintly yellow
• GHS警示词: Danger
• GHS危险声明: H301
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 个人保护装置: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS警示性声明: P301 + P310
• RID/ADR: UN 3462 6.1/PG 3
• 危险公开号: 25
• RTECS编号: BZ9800000
• 安全公开号: 45
• 保存温度: 2-8°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 3462
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Other Notes
Inhibits formation of the 80S ribosomal complex from 60S subunits.1
Biochem/physiol Actions
Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. Reported to induce apoptosis in a variety of cells including promyelocytic leukemia cells, Jurkat cells, ventricular myocytes, and colon adenocarcinoma cells. Initiates intracellular signals and immediate early gene induction. Selective signaling agonist. Potent Jun-NH2 terminal kinase (JNK) agonist. Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK). Antiprotozoal agent.

详细说明 (简体中文)

Other Notes
Inhibits formation of the 80S ribosomal complex from 60S subunits.1
Biochem/physiol Actions
Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. Reported to induce apoptosis in a variety of cells including promyelocytic leukemia cells, Jurkat cells, ventricular myocytes, and colon adenocarcinoma cells. Initiates intracellular signals and immediate early gene induction. Selective signaling agonist. Potent Jun-NH2 terminal kinase (JNK) agonist. Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK). Antiprotozoal agent.