(±)-Miconazole nitrate salt

• 产品号: PHR1163
• CAS号: 22832-87-7
• 分子式: C18H15Cl4N3O4
• 分子量: 479.1414

产品别名

• 标题: (±)-Miconazole nitrate salt
• IUPAC标准名: 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole; nitric acid
• IUPAC传统名: acid, nitric; miconazole
• 别名: 1-(2,4-Dichloro-β-[(2,4-dichlorobenzyl)oxy]phenethyl)imidazole

产品登记号

• MDL号: MFCD00058161
• EC号: 245-256-6
• CAS号: 22832-87-7

产品性质

• Empirical Formula (Hill Notation): C18H14Cl4N2O · HNO3
• 级别: certified reference material
• 包装: pkg of 1 g
• Pharmacopeia Traceability: traceable to BP 253
• Pharmacopeia Traceability: traceable to PhEur M1900000
• Pharmacopeia Traceability: traceable to USP 1443500
• GHS警示词: Warning
• GHS危险声明: H302-H317
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• GHS警示性声明: P280
• 危险公开号: 22-43
• 安全公开号: 36/37
• 保存温度: room temp
• 德国WGK号: 3

产品详细信息

详细说明 (English)

General description
This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO Guide 34.
Other Notes
Values of analytes vary lot to lot.
Biochem/physiol Actions
Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for ergosterol biosynthesis. The inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with phospholipids in the cell membrane, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and interfere with triglyceride and phospholipid biosynthesis.

详细说明 (简体中文)

General description
This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO Guide 34.
Other Notes
Values of analytes vary lot to lot.
Biochem/physiol Actions
Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for ergosterol biosynthesis. The inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with phospholipids in the cell membrane, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and interfere with triglyceride and phospholipid biosynthesis.