(±)-Verapamil hydrochloride

• 产品号: PHR1131
• CAS号: 152-11-4
• 分子式: C27H39ClN2O4
• 分子量: 491.06256

产品别名

• 标题: (±)-Verapamil hydrochloride
• IUPAC标准名: 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile hydrochloride
• IUPAC传统名: veraβ hydrochloride
• 别名: 5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride

产品登记号

• EC号: 205-800-5
• CAS号: 152-11-4
• Beilstein号: 3647093
• MDL号: MFCD00055208

产品性质

• 级别: certified reference material
• 线性分子式: (CH3O)2C6H3CH2CH2N(CH3)(CH2)3C[C6H3(OCH3)2][CH(CH3)2]CN · HCl
• 包装: pkg of 1 g
• Pharmacopeia Traceability: traceable to PhEur V0100000
• Pharmacopeia Traceability: traceable to USP 1711202
• 熔点: 142 °C (dec.)(lit.)
• GHS警示词: Danger
• GHS危险声明: H301-H311-H331
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• GHS警示性声明: P261-P280-P301 + P310-P311
• 危险公开号: 23/24/25
• 安全公开号: 36/37-45
• 保存温度: room temp
• 德国WGK号: 3

产品详细信息

详细说明 (简体中文)

General description
This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO Guide 34.
Other Notes
Values of analytes vary lot to lot.
Biochem/physiol Actions
α1-adrenoceptor antagonist; L-type calcium channel blocker. Blocks L-type Ca2+ channels in smooth and cardiac muscle, induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro. Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin. Increases basal ATPase activity of Pgp. Substrate of Cyp3A4 and CYP2C6.

详细说明 (English)

General description
This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO Guide 34.
Other Notes
Values of analytes vary lot to lot.
Biochem/physiol Actions
α1-adrenoceptor antagonist; L-type calcium channel blocker. Blocks L-type Ca2+ channels in smooth and cardiac muscle, induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro. Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin. Increases basal ATPase activity of Pgp. Substrate of Cyp3A4 and CYP2C6.