2,5-Dimethyl-celecoxib

• 产品号: 35342
• CAS号: 457639-26-8
• 分子式: C18H16F3N3O2S
• 分子量: 395.3987496

产品别名

• 标题: 2,5-Dimethyl-celecoxib
• IUPAC标准名: 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene-1-sulfonamide
• IUPAC传统名: 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
• 别名: 2,5-Dimethylcelecoxib; 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide

产品登记号

• MDL号: MFCD19443858
• CAS号: 457639-26-8

产品性质

• Empirical Formula (Hill Notation): C18H16F3N3O2S
• 级别: VETRANAL™, analytical standard
• GHS警示词: Danger
• GHS危险声明: H301
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• GHS警示性声明: P301 + P310
• 危险公开号: 25
• 安全公开号: 45
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Celecoxib, and the inactive analog 2′,5′-dimethyl celecoxib both induce apoptosis in a many cancer cell lines by down-regulating the expression of survivin. This activiy is mediated via an AKT mediated pathway, and is unique to this class of cyclo-oxygenase inhibitors, as non-selective NSAIDs or other COX-2 specific inhibitors such as rofecoxib, do not effect survivin expression. Unlike celecoxib, 2′,5′-dimethyl celecoxib is devoid of any inhibitory activity against COX-2.
Legal Information
VETRANAL is a trademark of Sigma-Aldrich Co. LLC

详细说明 (简体中文)

Biochem/physiol Actions
Celecoxib, and the inactive analog 2′,5′-dimethyl celecoxib both induce apoptosis in a many cancer cell lines by down-regulating the expression of survivin. This activiy is mediated via an AKT mediated pathway, and is unique to this class of cyclo-oxygenase inhibitors, as non-selective NSAIDs or other COX-2 specific inhibitors such as rofecoxib, do not effect survivin expression. Unlike celecoxib, 2′,5′-dimethyl celecoxib is devoid of any inhibitory activity against COX-2.
法律信息
VETRANAL 商标 Sigma-Aldrich Co. LLC