Retinoic acid

• 产品号: 95152
• CAS号: 302-79-4
• 分子式: C20H28O2
• 分子量: 300.43512
• 纯 度: ≥98.0% (HPLC)

产品别名

• 标题: Retinoic acid
• IUPAC标准名: 3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
• IUPAC传统名: isotretinoin
• 别名: tretinoin; ATRA; all-trans-Retinoic acid; Vitamin A acid

产品登记号

• EC号: 206-129-0
• MDL号: MFCD00001551
• CAS号: 302-79-4
• Beilstein号: 2057223

产品性质

• Empirical Formula (Hill Notation): C20H28O2
• 燃烧残渣: ≤0.1% (as SO4)
• 杂质: ≤0.002% heavy metals
• 干燥失重: ≤0.5% loss on drying
• 纯度: ≥98.0% (HPLC)
• 相关基因信息: human ... RARA(5914), RARB(5915), RARG(5916)
• 熔点: 180-181 °C(lit.)
• 熔点: 182-186 °C
• GHS警示词: Warning
• GHS危险声明: H302-H411
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P273
• 危险公开号: 22-51/53
• RTECS编号: VH6475000
• 安全公开号: 61
• 保存温度: 2-8°C
• 德国WGK号: 2

产品详细信息

详细说明 (English)

Other Notes
Review: Retinoic acid metabolism1
Unit Definition
1 U corresponds to 1 international U acc. to Ph Eur II, 217 (1983)
Biochem/physiol Actions
all-trans-Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.

详细说明 (简体中文)

Other Notes
Review: Retinoic acid metabolism1
Unit Definition
1 U corresponds to 1 international U acc. to Ph Eur II, 217 (1983)
Biochem/physiol Actions
all-trans-Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.