氯霉素

• 产品号: 23275
• CAS号: 56-75-7
• 分子式: C11H12Cl2N2O5
• 分子量: 323.12938
• 纯 度: ≥99.0% (HPLC)

产品别名

• 标题: Chloramphenicol
• IUPAC标准名: 2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
• IUPAC传统名: chloromycetin
• 别名: D(-)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide; D-(-)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol; D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]acetamide; D-(-)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide; Chloromycetin

产品登记号

• MDL号: MFCD00078159
• Beilstein号: 2225532
• CAS号: 56-75-7
• EC号: 200-287-4

产品性质

• 线性分子式: Cl2CHCONHCH(CH2OH)CH(OH)C6H4NO2
• 纯度: ≥99.0% (HPLC)
• 熔点: 148-150 °C(lit.)
• 熔点: 149-151 °C
• 比旋光度: [α]20/D +19.5±1°, c = 5% in ethanol
• GHS警示词: Danger
• GHS危险声明: H350
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 个人保护装置: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS警示性声明: P201-P308 + P313
• 危险公开号: 45
• RTECS编号: AB6825000
• 安全公开号: 53-45
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Mode of Action: Inhibits translation on the 50S ribosomal subunit at the peptidyltransferase step (elongation inhibition). Bacteriostatic.Mode of Resistance: Acetylation by chloramphenicol acetyltransferase (cat gene).
Other Notes
Inhibits protein biosynthesis by binding to the large subunit of the bacterial ribosome and by blocking the peptidyl transfer; chloramphenicol-resistance is a useful genetic marker for the selection of eukaryotic cells;1 Resistance is usually mediated by a chloramphenicol-acetyl-transferase, but there are exceptions;2 Review.3

详细说明 (简体中文)

Biochem/physiol Actions
Mode of Action: Inhibits translation on the 50S ribosomal subunit at the peptidyltransferase step (elongation inhibition). Bacteriostatic.Mode of Resistance: Acetylation by chloramphenicol acetyltransferase (cat gene).
Other Notes
通过结合到细菌核糖体的大亚基上以及通过阻断肽基转移从而抑制蛋白质的生物合成；氯霉素抗性是一种用于筛选真核细胞的有用遗传标记；1抗性通常由氯霉素乙酰转移酶介导，但也存在例外；2综述。3