6-硫鸟嘌呤

• 产品号: 88800
• CAS号: 154-42-7
• 分子式: C5H5N5S
• 分子量: 167.1917
• 纯 度: ≥96% (HPLC)

产品别名

• 标题: 6-Thioguanine
• IUPAC标准名: 2-amino-6,7-dihydro-1H-purine-6-thione
• IUPAC传统名: 2-aminopurine-6(1h)-thione
• 别名: 2-氨基-6-巯嘌呤; 2-Amino-6-purinethiol; 2-Amino-6-mercaptopurine; 2-氨基-6巯基嘌呤

产品登记号

• CAS号: 154-42-7
• Beilstein号: 157765
• MDL号: MFCD00233553
• EC号: 205-827-2

产品性质

• Empirical Formula (Hill Notation): C5H5N5S
• 级别: purum
• 杂质: ≤3% guanine
• 纯度: ≥96% (HPLC)
• 熔点: ≥300 °C(lit.)
• GHS警示词: Danger
• GHS危险声明: H301
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 个人保护装置: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS警示性声明: P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• 危险公开号: 25
• RTECS编号: UP0740000
• 安全公开号: 28-36/37/39-45
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Other Notes
Antineoplastic agent2; substrate for HGPRTase, converted to 6-thio-GMP, which then inhibits vital metabolic sequences in myelocytic and acute lymphocytic leukemia.1
Biochem/physiol Actions
Ribosylated and phosphorylated by the same pathway as natural purine bases; as the nucleotide, inhibits a variety of cellular processes involved in nucleic acid synthesis. Has a long history as an effective treatment of leukemia.1

详细说明 (简体中文)

Other Notes
Antineoplastic agent2; substrate for HGPRTase, converted to 6-thio-GMP, which then inhibits vital metabolic sequences in myelocytic and acute lymphocytic leukemia.1
Biochem/physiol Actions
Ribosylated and phosphorylated by the same pathway as natural purine bases; as the nucleotide, inhibits a variety of cellular processes involved in nucleic acid synthesis. Has a long history as an effective treatment of leukemia.1