P1,P5-Di(adenosine-5′) pentaphosphate trilithium salt

• 产品号: 31583
• CAS号: 75522-97-3
• 分子式: C20H24Li5N10O22P5
• 分子量: 946.032165
• 纯 度: ≥95% (HPLC)

产品别名

• 标题: P1,P5-Di(adenosine-5′) pentaphosphate trilithium salt
• IUPAC标准名: pentalithium(1+) ion ({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxy)[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxy)phosphinato]oxy}phosphinato)oxy]phosphinate
• IUPAC传统名: pentalithium(1+) ion Ap5A
• 别名: A(5′)P5(5′)A trilithium salt; Diadenosine pentaphosphate trilithium salt

产品登记号

• CAS号: 75522-97-3
• EC号: 302-339-2
• MDL号: MFCD00044936

产品性质

• Empirical Formula (Hill Notation): C20H26Li3N10O22P5
• 杂质: ≤5% water
• 纯度: ≥95% (HPLC)
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
A diadenosine polyphosphate stored in secretory granules of thrombocytes, chromaffin and neuronal cells. After release into the extracellular space, it affects a variety of biological activities in a wide range of target tissues. In the nervous system it acts through various purinergic receptors. It also activates 5′-nucleotidase and inhibits adenosine kinase activity in vitro. Ap5A is metabolized by soluble enzymes in the blood plasma and by membrane-bound ectoenzymes of a number of cell types including endothelial and smooth muscle cells. In cardiac muscle, pM to nM concentrations significantly increase the open-probability of ryanodine-receptor (RyR2) gates, with prolonged action due to slow dissociation from the receptor.1

详细说明 (简体中文)

Biochem/physiol Actions
A diadenosine polyphosphate stored in secretory granules of thrombocytes, chromaffin and neuronal cells. After release into the extracellular space, it affects a variety of biological activities in a wide range of target tissues. In the nervous system it acts through various purinergic receptors. It also activates 5′-nucleotidase and inhibits adenosine kinase activity in vitro. Ap5A is metabolized by soluble enzymes in the blood plasma and by membrane-bound ectoenzymes of a number of cell types including endothelial and smooth muscle cells. In cardiac muscle, pM to nM concentrations significantly increase the open-probability of ryanodine-receptor (RyR2) gates, with prolonged action due to slow dissociation from the receptor.1