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P1,P5-Di(adenosine-5′) pentaphosphate pentasodium salt_分子结构_CAS_4097-04-5)
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P1,P5-Di(adenosine-5′) pentaphosphate pentasodium salt

产品号 31588 公司名称 Sigma Aldrich
CAS号 4097-04-5 公司网站 http://www.sigmaaldrich.com
分子式 C20H24N10Na5O22P5 电 话 1-800-521-8956
分子量 1026.276015 传 真
纯 度 ≥96.0% (HPLC) 电子邮件
保 存 Chembase数据库ID: 155104

产品价格信息

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产品别名

标题
P1,P5-Di(adenosine-5′) pentaphosphate pentasodium salt
IUPAC标准名
pentasodium ({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxy)[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxy)phosphinato]oxy}phosphinato)oxy]phosphinate
IUPAC传统名
pentasodium Ap5A
别名
Diadenosine pentaphosphate pentasodium salt
A(5′)P5(5′)A

产品登记号

Beilstein号 4949216
CAS号 4097-04-5
MDL号 MFCD00077718
EC号 223-852-7

产品性质

线性分子式 C20H29N10O22P5 · 5 Na
纯度 ≥96.0% (HPLC)
溶解度 H2O: soluble50 mg/mL, clear, slightly yellow
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个人保护装置 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
保存温度 -20°C
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
A diadenosine polyphosphate stored in secretory granules of thrombocytes, chromaffin and neuronal cells. After release into the extracellular space, it affects a variety of biological activities in a wide range of target tissues. In the nervous system it acts through various purinergic receptors. It also activates 5′-nucleotidase and inhibits adenosine kinase activity in vitro. Ap5A is metabolized by soluble enzymes in the blood plasma and by membrane-bound ectoenzymes of a number of cell types including endothelial and smooth muscle cells. In cardiac muscle, pM to nM concentrations significantly increase the open-probability of ryanodine-receptor (RyR2) gates, with prolonged action due to slow dissociation from the receptor.1
详细说明 (简体中文)
Biochem/physiol Actions
A diadenosine polyphosphate stored in secretory granules of thrombocytes, chromaffin and neuronal cells. After release into the extracellular space, it affects a variety of biological activities in a wide range of target tissues. In the nervous system it acts through various purinergic receptors. It also activates 5′-nucleotidase and inhibits adenosine kinase activity in vitro. Ap5A is metabolized by soluble enzymes in the blood plasma and by membrane-bound ectoenzymes of a number of cell types including endothelial and smooth muscle cells. In cardiac muscle, pM to nM concentrations significantly increase the open-probability of ryanodine-receptor (RyR2) gates, with prolonged action due to slow dissociation from the receptor.1

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