P1,P5-Di(adenosine-5′) pentaphosphate pentasodium salt

• 产品号: 31588
• CAS号: 4097-04-5
• 分子式: C20H24N10Na5O22P5
• 分子量: 1026.276015
• 纯 度: ≥96.0% (HPLC)

产品别名

• 标题: P1,P5-Di(adenosine-5′) pentaphosphate pentasodium salt
• IUPAC标准名: pentasodium ({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxy)[({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxy)phosphinato]oxy}phosphinato)oxy]phosphinate
• IUPAC传统名: pentasodium Ap5A
• 别名: Diadenosine pentaphosphate pentasodium salt; A(5′)P5(5′)A

产品登记号

• Beilstein号: 4949216
• CAS号: 4097-04-5
• MDL号: MFCD00077718
• EC号: 223-852-7

产品性质

• 线性分子式: C20H29N10O22P5 · 5 Na
• 纯度: ≥96.0% (HPLC)
• 溶解度: H2O: soluble50 mg/mL, clear, slightly yellow
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
A diadenosine polyphosphate stored in secretory granules of thrombocytes, chromaffin and neuronal cells. After release into the extracellular space, it affects a variety of biological activities in a wide range of target tissues. In the nervous system it acts through various purinergic receptors. It also activates 5′-nucleotidase and inhibits adenosine kinase activity in vitro. Ap5A is metabolized by soluble enzymes in the blood plasma and by membrane-bound ectoenzymes of a number of cell types including endothelial and smooth muscle cells. In cardiac muscle, pM to nM concentrations significantly increase the open-probability of ryanodine-receptor (RyR2) gates, with prolonged action due to slow dissociation from the receptor.1

详细说明 (简体中文)

Biochem/physiol Actions
A diadenosine polyphosphate stored in secretory granules of thrombocytes, chromaffin and neuronal cells. After release into the extracellular space, it affects a variety of biological activities in a wide range of target tissues. In the nervous system it acts through various purinergic receptors. It also activates 5′-nucleotidase and inhibits adenosine kinase activity in vitro. Ap5A is metabolized by soluble enzymes in the blood plasma and by membrane-bound ectoenzymes of a number of cell types including endothelial and smooth muscle cells. In cardiac muscle, pM to nM concentrations significantly increase the open-probability of ryanodine-receptor (RyR2) gates, with prolonged action due to slow dissociation from the receptor.1