Wortmannin

• 产品号: 95455
• CAS号: 19545-26-7
• 分子式: C23H24O8
• 分子量: 428.43186
• 纯 度: ≥98.0% (TLC)

产品别名

• 标题: Wortmannin
• IUPAC标准名: (1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.0^2,^1^0.0^5,^9.0^1^5,^1^9]nonadeca-2(10),12(19),14-trien-3-yl acetate
• IUPAC传统名: wortmannin
• 别名: KY 12420

产品登记号

• CAS号: 19545-26-7
• MDL号: MFCD00133927
• Beilstein号: 67676

产品性质

• Empirical Formula (Hill Notation): C23H24O8
• 纯度: ≥98.0% (TLC)
• GHS警示词: Danger
• GHS危险声明: H300-H310-H330
• 欧盟危险性物质标志: 剧毒(Highly toxic) (T+)
• 个人保护装置: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS警示性声明: P260-P264-P280-P284-P302 + P350-P310
• RID/ADR: UN 3462 6.1/PG 1
• 危险公开号: 26/27/28
• RTECS编号: CB9641000
• 安全公开号: 28-36/37-45
• 保存温度: 2-8°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 3462
• 联合国危险货物包装类别(PG): 1
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor with an IC50 of 2-4 nM. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Inhibition of PI3-K by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation.

详细说明 (简体中文)

Biochem/physiol Actions
Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor with an IC50 of 2-4 nM. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Inhibition of PI3-K by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation.