二甲双胍 盐酸盐

• 产品号: 04635
• CAS号: 1115-70-4
• 分子式: C4H12ClN5
• 分子量: 165.62458

产品别名

• 标题: Metformin hydrochloride
• IUPAC标准名: 1-carbamimidamido-N,N-dimethylmethanimidamide hydrochloride
• IUPAC传统名: metformin hydrochloride
• 别名: 1,1-Dimethylbiguanide hydrochloride; 甲福明 盐酸盐; 二甲双胍; Metformin

产品登记号

• MDL号: MFCD00012582
• EC号: 214-230-6
• CAS号: 1115-70-4

产品性质

• 线性分子式: NH2C(=NH)NHC(=NH)N(CH3)2 · HCl
• Pharmacopeia Traceability: traceable to PhEur M0605000
• Pharmacopeia Traceability: traceable to USP 1396309
• 熔点: 223-226 °C(lit.)
• GHS警示词: Warning
• GHS危险声明: H302-H315-H319
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• GHS警示性声明: P305 + P351 + P338
• 危险公开号: 22-36/38
• RTECS编号: DU1800000
• 安全公开号: 26-36
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Metformin is an antidiabetic agent that reduces blood glucose levels and improves insulin sensitivity. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated at least in part by activation of the LKB1-AMPK (AMP-activated protein kinase) pathway. Activation of this pathway also appears to be involved in the antiproliferative and proapoptotic actions of metformin in cancer cell lines.

详细说明 (简体中文)

Biochem/physiol Actions
甲福明是一种抗糖尿病药，可降低血糖水平，提高胰岛素灵敏度。其代谢作用（包括抑制肝脏糖异生作用）至少部分是通过激活 LKB1-AMPK（AMP-活化蛋白激酶）通路进行介导。该通路的激活也涉及到癌细胞系中甲福明的抗增殖和促凋亡作用。