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N-(2-芴基)乙酰胺_分子结构_CAS_53-96-3)
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N-(2-芴基)乙酰胺

产品号 00300 公司名称 Sigma Aldrich
CAS号 53-96-3 公司网站 http://www.sigmaaldrich.com
分子式 C15H13NO 电 话 1-800-521-8956
分子量 223.26982 传 真
纯 度 ≥95.0% (CHN) 电子邮件
保 存 Chembase数据库ID: 125243

产品价格信息

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产品别名

标题
N-(2-Fluorenyl)acetamide
IUPAC标准名
N-(9H-fluoren-2-yl)acetamide
IUPAC传统名
2 acetylaminofluorene
别名
2-AAF
N-乙酰基-2-氨基芴
2-Acetamidofluorene
2-乙酰氨基芴
N-Acetyl-2-aminofluorene

产品登记号

MDL号 MFCD00001116
EC号 200-188-6
Beilstein号 2807677
CAS号 53-96-3

产品性质

Empirical Formula (Hill Notation) C15H13NO
级别 purum
纯度 ≥95.0% (CHN)
熔点 192-196 °C(lit.)
GHS危险品标识 GHS07
GHS危险品标识 GHS08
GHS警示词 Danger
GHS危险声明 H302-H350
欧盟危险性物质标志 有毒(Toxic) 有毒(Toxic) (T)
MSDS下载 下载链接
个人保护装置 Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS警示性声明 P201-P308 + P313
RID/ADR UN 3077 9/PG 3
危险公开号 45-22
RTECS编号 AB9450000
安全公开号 53-36/37/39-45
联合国危险货物等级 9
联合国危险货物编号 3077
联合国危险货物包装类别(PG) 3
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
A genotoxic carcinogen that is used to model liver carcinogenesis in rat. When N-hydroxylated by cytochrome CYP1A2 in the liver, 2-AAF forms adducts with DNA and is tumorigenic in liver and bladder.
Application
N-(2-fluorenyl)acetamide is a hepatic carcinogen whose principle target protein is the liver fatty acid binding protein (L-FABP). N-(2-Fluorenyl)acetamide has been used in a study to establish a hepatoma model to study the dynamic expression and quantitative analysis of hepatic nuclear factor-kappa B and its gene during the development of hepatocellular carcinoma.
详细说明 (简体中文)
Biochem/physiol Actions
一种遗传毒性致癌物,用于诱发大鼠肝癌模型。当因肝脏中的细胞色素 CYP1A2 发生 N-羟基化时,2-AAF 与 DNA 形成加合物,在肝脏和膀胱中发生肿瘤。
Application
N-(2-fluorenyl)acetamide is a hepatic carcinogen whose principle target protein is the liver fatty acid binding protein (L-FABP). N-(2-Fluorenyl)acetamide has been used in a study to establish a hepatoma model to study the dynamic expression and quantitative analysis of hepatic nuclear factor-kappa B and its gene during the development of hepatocellular carcinoma.

参考文献