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D-2-脱氧葡萄糖_分子结构_CAS_154-17-6)
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D-2-脱氧葡萄糖

产品号 31060 公司名称 Sigma Aldrich
CAS号 154-17-6 公司网站 http://www.sigmaaldrich.com
分子式 C6H12O5 电 话 1-800-521-8956
分子量 164.15648 传 真
纯 度 ≥98.0% (HPLC) 电子邮件
保 存 Chembase数据库ID: 105767

产品价格信息

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产品别名

标题
2-Deoxy-D-glucose
IUPAC标准名
(3R,4S,5R)-3,4,5,6-tetrahydroxyhexanal
IUPAC传统名
deoxyglucose
别名
2-脱氧-D-葡糖
2-Deoxy-D-arabinohexose

产品登记号

CAS号 154-17-6
MDL号 MFCD00151328
EC号 205-823-0
Beilstein号 1723331

产品性质

Empirical Formula (Hill Notation) C6H12O5
纯度 ≥98.0% (HPLC)
熔点 146-147 °C(lit.)
熔点 148-153 °C
比旋光度 [α]20/D +46.5±2°, 45 hr, c = 0.5% in H2O
溶解度 H2O: soluble50 mg/mL, clear, colorless to faintly yellow
MSDS下载 下载链接
个人保护装置 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.1
详细说明 (简体中文)
Biochem/physiol Actions
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.1

参考文献