胆钙化醇

• 产品号: 89193
• CAS号: 67-97-0
• 分子式: C27H44O
• 分子量: 384.63766

产品别名

• 标题: Cholecalciferol
• IUPAC标准名: (1S)-3-{2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexan-1-ol
• IUPAC传统名: cholecalciferol
• 别名: (+)-Vitamin D3; Calciol; Cholecalciferolum; Activated 7-dehydrocholesterol; 7-Dehydrocholesterol activated; 胆钙化醇; (+)-维生素 D3; 活化7-脱氢胆固醇; 活化7-脱氢胆甾醇; 胆骨化醇

产品登记号

• EC号: 200-673-2
• MDL号: MFCD00078131
• Beilstein号: 2339331
• PubChem SID: 24889192
• CAS号: 67-97-0

产品性质

• Empirical Formula (Hill Notation): C27H44O
• 级别: Ph Eur
• 药典: testing & handling conforms to Pharmacopeia
• 熔点: 83-86 °C(lit.)
• GHS警示词: Danger
• GHS危险声明: H301-H311-H330-H372
• 欧盟危险性物质标志: 剧毒(Highly toxic) (T+)
• 个人保护装置: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS警示性声明: P260-P280-P284-P301 + P310-P310
• RID/ADR: UN 2811 6.1/PG 2
• 危险公开号: 24/25-26-48/25
• RTECS编号: VS2900000
• 安全公开号: 28-36/37-45
• 保存温度: 2-8°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 2
• 德国WGK号: 2

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.

详细说明 (简体中文)

Biochem/physiol Actions
维生素 D 借以发挥作用的受体是配体依赖性转录因子超家族的成员。调控正常细胞和癌细胞的增殖和分化。对乳腺癌、结肠癌和前列腺癌细胞具有抗增殖和抗转移作用。肠和骨骼中的活化维生素 D 受体维持着钙的吸收和平衡。