钙离子载体 A23187

• 产品号: 21045
• CAS号: 52665-69-7
• 分子式: C29H37N3O6
• 分子量: 523.62058
• 纯 度: ~95% (HPLC)

产品别名

• 标题: Calcium Ionophore A23187
• IUPAC标准名: 5-(methylamino)-2-{[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-2-yl]methyl}-1,3-benzoxazole-4-carboxylic acid
• IUPAC传统名: 5-(methylamino)-2-{[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-2-yl]methyl}-1,3-benzoxazole-4-carboxylic acid
• 别名: Calimycin; 钙离子载体; 抗生素 A 23187; Antibiotic A 23187

产品登记号

• MDL号: MFCD00151202
• EC号: 258-084-1
• CAS号: 52665-69-7
• Beilstein号: 1096801

产品性质

• Empirical Formula (Hill Notation): C29H37N3O6
• 纯度: ~95% (HPLC)
• 熔点: 187-190 °C
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• RTECS编号: DM4676000
• 安全公开号: 26-36
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
Ionophore highly selective for Ca2+. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase.
Other Notes
A23187 increases the permeability of biological membranes with a high selectivity for Ca2+. It is used extensively in studies related to intracellular Ca2+,1,2,3

详细说明 (简体中文)

Application
高选择性钙离子载体增强对 NMDA 非使君子氨酸的响应。在细胞培养中，通过钙调素依赖结构型一氧化氮合酶刺激一氧化氮的生成。
Other Notes
A23187 increases the permeability of biological membranes with a high selectivity for Ca2+. It is used extensively in studies related to intracellular Ca2+,1,2,3