放线菌素 D

• 产品号: 01817
• CAS号: 50-76-0
• 分子式: C62H86N12O16
• 分子量: 1255.41704
• 纯 度: ≥98.0% (HPLC)

产品别名

• 标题: Actinomycin D
• IUPAC标准名: 1-N,9-N-bis[(6S,9R,10S,13R,18aS)-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-6,13-bis(propan-2-yl)-hexadecahydro-1H-pyrrolo[2,1-i]1-oxa-4,7,10,13-tetraazacyclohexadecan-10-yl]-2-amino-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide
• IUPAC传统名: actinomycin D
• 别名: 更生霉素; Actinomycin C1; Actinomycin IV; Dactinomycin; 放线菌素 C1; 放线菌素 IV

产品登记号

• CAS号: 50-76-0
• Beilstein号: 605235
• EC号: 200-063-6
• MDL号: MFCD00005033

产品性质

• 生物来源: from Streptomyces sp.
• Empirical Formula (Hill Notation): C62H86N12O16
• 纯度: ≥98.0% (HPLC)
• 外观: red, powder
• 熔点: 251-253
• 溶解度: acetonitrile: soluble10 mg/mL, clear, orange to red
• GHS警示词: Danger
• GHS危险声明: H300
• 欧盟危险性物质标志: 剧毒(Highly toxic) (T+)
• 个人保护装置: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS警示性声明: P264-P301 + P310
• RID/ADR: UN 3462 6.1/PG 2
• 危险公开号: 28
• RTECS编号: AU1575000
• 安全公开号: 22-28-36/37-45
• 保存温度: 2-8°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 3462
• 联合国危险货物包装类别(PG): 2
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes.
Other Notes
Inhibits DNA-dependent RNA synthesis. DNA-binding drug1,2,3

详细说明 (简体中文)

Biochem/physiol Actions
An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes.
Other Notes
Inhibits DNA-dependent RNA synthesis. DNA-binding drug1,2,3