氟磷酸二异丙酯

• 产品号: 38399
• CAS号: 55-91-4
• 分子式: C6H14FO3P
• 分子量: 184.1457242
• 纯 度: ≥97.0% (GC)

产品别名

• 标题: Diisopropylfluorophosphate
• IUPAC标准名: bis(propan-2-yl) fluorophosphonate
• IUPAC传统名: isoflurophate
• 别名: Phosphoric acid diisopropyl ester fluoride; DFP; 二异丙基氟磷酸酯; Diisopropyl phosphorofluoridate; DIFP; 氟代磷酸二异丙酯

产品登记号

• CAS号: 55-91-4
• MDL号: MFCD00008873
• PubChem SID: 24863641
• EC号: 200-247-6
• Beilstein号: 1723307

产品性质

• 线性分子式: [(CH3)2CHO]2POF
• 纯度: ≥97.0% (GC)
• 相关基因信息: human ... PTGS1(5742), PTGS2(5743)
• 沸点: 62 °C/9 mmHg(lit.)
• 密度: 1.06 g/mL at 25 °C(lit.)
• 熔点: -82 °C(lit.)
• 折射率: n20/D 1.385(lit.)
• 蒸汽压: 0.58 mmHg ( 20 °C)
• GHS警示词: Danger
• GHS危险声明: H300 +H310 + H330
• 欧盟危险性物质标志: 剧毒(Highly toxic) (T+)
• 个人保护装置: Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• GHS警示性声明: P260-P264-P280-P284-P301 + P310-P302 + P350
• RID/ADR: UN 3382 6.1/PG 1
• 危险公开号: 26/27/28
• RTECS编号: TE5075000
• 安全公开号: 36/37/39-45
• 保存温度: 2-8°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 3382
• 联合国危险货物包装类别(PG): 1
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Analysis Note
Typically used at a concentration of 0.10 mM. A safer alternative inhibitor for serine protease is phenylmethylsulfonyl fluoride (PMSF).
Other Notes
Potent inhibitor of chymotrypsin and other enzymes (e.g. serine hydrolases)1; Inhibition of carboxypeptidase but not DAP I2
Biochem/physiol Actions
Potent inhibitor of serine proteases such as trypsin and chymotrypsin, and of acetylcholinesterase; also inhibits cathepsin G, cholinesterase, coagulation factor Xa, leucocyte elastase, pancreatic elastase, tissue kallikrein, plasmin, subtilisin, and thrombin. Inhibition of acetylcholinesterase makes this compound especially toxic. Inhibits apoptosis induced by ricin and bacterial toxins.

详细说明 (简体中文)

Analysis Note
使用浓度通常为 0.10mM。苯甲基磺酰氟 (PMSF) 是一种更安全的丝氨酸蛋白酶替代抑制剂。
Other Notes
Potent inhibitor of chymotrypsin and other enzymes (e.g. serine hydrolases)1; Inhibition of carboxypeptidase but not DAP I2
Biochem/physiol Actions
丝氨酸蛋白酶（如胰蛋白酶和胰凝乳蛋白酶）和乙酰胆碱酯酶的强效抑制剂；还抑制组织蛋白酶 G、胆碱脂酶、凝血因子 Xa、白细胞弹性蛋白酶、胰弹性蛋白酶、组织激肽释放酶、血纤维蛋白熔酶、枯草杆菌蛋白酶以及凝血酶。乙酰胆碱酯酶的抑制作用使该化合物具有特别强的毒性。抑制由篦麻毒素和细菌毒素诱导的细胞凋亡。