氨苄西林 三水合物

• 产品号: 10045
• CAS号: 7177-48-2
• 分子式: C16H25N3O7S
• 分子量: 403.4506
• 纯 度: ≥96.0% (NT)

产品别名

• 标题: Ampicillin trihydrate
• IUPAC标准名: (2S,5R,6R)-6-[(2R)-2-amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate
• IUPAC传统名: ampicillin trihydrate
• 别名: D-(-)-α-Aminobenzylpenicillin; 氨苄青霉素

产品登记号

• CAS号: 7177-48-2
• Beilstein号: 5399534
• MDL号: MFCD00072036
• EC号: 200-709-7

产品性质

• Empirical Formula (Hill Notation): C16H19N3O4S · 3H2O
• 燃烧残渣: ≤0.05%
• 纯度: ≥96.0% (NT)
• 熔点: 198-200 °C (dec.)(lit.)
• 熔点: 200-202 °C (dec.)
• 比旋光度: [α]20/D +250±10°, c = 0.5% in H2O
• GHS警示词: Danger
• GHS危险声明: H315-H317-H319-H334-H335
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS警示性声明: P261-P280-P305 + P351 + P338-P342 + P311
• 危险公开号: 36/37/38-42/43
• RTECS编号: XH8425000
• 安全公开号: 22-26-36/37
• 保存温度: 2-8°C
• 德国WGK号: 2

产品详细信息

详细说明 (English)

Biochem/physiol Actions
A β-lactam antibiotic with an amino group side chain attached to the penicillin structure. Penicillin derivative that inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Bactericidal only to growing Escherichia coli . Mode of resistance: Cleavage of β-lactam ring of ampicillin by β-lactamase. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Application
Ampicillin Trihydrate is commonly used to select for ampicillin resistance in mutated and transformed cells. It is used in intracellular targeting of antibiotics on biodegradable polymeric carriers 1. Nanoparticle-bound ampicillin has been shown to be more effective than free ampicillin against Listeria monocytogenes in mouse peritoneal macrophages2. Ampicillin has been shown to cause Clostridium difficile-Associated ileocecitis in the hamster model3.

详细说明 (简体中文)

Biochem/physiol Actions
A β-lactam antibiotic with an amino group side chain attached to the penicillin structure. Penicillin derivative that inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Bactericidal only to growing Escherichia coli . Mode of resistance: Cleavage of β-lactam ring of ampicillin by β-lactamase. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Application
Ampicillin Trihydrate is commonly used to select for ampicillin resistance in mutated and transformed cells. It is used in intracellular targeting of antibiotics on biodegradable polymeric carriers 1. Nanoparticle-bound ampicillin has been shown to be more effective than free ampicillin against Listeria monocytogenes in mouse peritoneal macrophages2. Ampicillin has been shown to cause Clostridium difficile-Associated ileocecitis in the hamster model3.