阿霉素 盐酸盐

• 产品号: 44583
• CAS号: 25316-40-9
• 分子式: C27H30ClNO11
• 分子量: 579.9802
• 纯 度: 98.0-102.0% (HPLC)

产品别名

• 标题: Doxorubicin hydrochloride
• IUPAC标准名: (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione hydrochloride
• IUPAC传统名: doxorubicin hydrochloride
• 别名: 羟基柔红霉素 盐酸盐; DOX; 多柔比星® 盐酸盐; Hydroxydaunorubicin hydrochloride

产品登记号

• Beilstein号: 4229251
• CAS号: 25316-40-9
• EC号: 246-818-3
• MDL号: MFCD00077757
• PubChem SID: 24868204

产品性质

• Empirical Formula (Hill Notation): C27H29NO11 · HCl
• 纯度: 98.0-102.0% (HPLC)
• 适用性: suitable for fluorescence
• 荧光: λex 470 nm; λem 585 nm in ethanol
• 熔点: 216 °C (dec.)(lit.)
• 溶解度: H2O: soluble50 mg/mL, clear, orange to red
• 溶解度: DMSO: soluble
• 溶解度: THF: soluble
• 溶解度: ethanol: soluble
• 溶解度: methanol: soluble
• GHS警示词: Danger
• GHS危险声明: H302-H315-H319-H350
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS警示性声明: P201-P305 + P351 + P338-P308 + P313
• 危险公开号: 45-22-36/38
• RTECS编号: QI9295900
• 安全公开号: 53-45
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (简体中文)

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Application
Do you have application information on this product that you would like to share?
Doxorubicin is used as an antitumour antibiotic, to induce apoptosis, and to induce cardiotoxicity in SK-N-MC cells 2,3.
Used to inhibit macromolecular biosynthsis.
Biochem/physiol Actions
Antitumour antibiotic. Effect of adriamycin® on heart mitochondrial DNA;4 Properties.5,6
Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent; intercalates in DNA.
Doxorubicin intercalates DNA and inhibits macromolecular biosynthesis. DNA replication is haulted due to the inhibition of topoisomerase II. It is an inhibitor of reverse transcriptase and RNA polymerase and is an immunosuppressive agent 1.
法律信息
Adriamycin 注册商标 RDF Pharmacia & Upjohn S.P.A.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

详细说明 (English)

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Application
Do you have application information on this product that you would like to share?
Doxorubicin is used as an antitumour antibiotic, to induce apoptosis, and to induce cardiotoxicity in SK-N-MC cells 2,3.
Used to inhibit macromolecular biosynthsis.
Biochem/physiol Actions
Antitumour antibiotic. Effect of adriamycin® on heart mitochondrial DNA;4 Properties.5,6
Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent; intercalates in DNA.
Doxorubicin intercalates DNA and inhibits macromolecular biosynthesis. DNA replication is haulted due to the inhibition of topoisomerase II. It is an inhibitor of reverse transcriptase and RNA polymerase and is an immunosuppressive agent 1.
Legal Information
Adriamycin is a registered trademark of RDF Pharmacia & Upjohn S.P.A.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information