5-Fluoro-L-tryptophan

• 产品号: 47568
• CAS号: 16626-02-1
• 分子式: C11H11FN2O2
• 分子量: 222.2156432
• 纯 度: ≥98.0% (HPLC)

产品别名

• 标题: 5-Fluoro-L-tryptophan
• IUPAC标准名: (2S)-2-amino-3-(5-fluoro-1H-indol-3-yl)propanoic acid
• IUPAC传统名: fluorotryptophane

产品登记号

• PubChem SID: 24871158
• CAS号: 16626-02-1
• MDL号: MFCD00066470
• Beilstein号: 5052680

产品性质

• Empirical Formula (Hill Notation): C11H11FN2O2
• 光学纯度: enantiomeric ratio: ≥99.5:0.5 (HPLC)
• 纯度: ≥98.0% (HPLC)
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
Exogenous 5-fluoro-Trp is incorporated into proteins in normal protein synthesis3. Since 19F is a useful reporter group, this provides a method for studying enzyme mechanisms by NMR4.
Biochem/physiol Actions
5-Fluoro-Trp is nonspecifically cytotoxic. It is believed this is due to malfunctioning enzymes that have had replacements of Trp residues by 5-fluoro-Trp.1 However, at least one case is known where 5-fluoro-Trp substitution leads to significantly greater catalytic activity.2

详细说明 (简体中文)

Application
Exogenous 5-fluoro-Trp is incorporated into proteins in normal protein synthesis3. Since 19F is a useful reporter group, this provides a method for studying enzyme mechanisms by NMR4.
Biochem/physiol Actions
5-Fluoro-Trp is nonspecifically cytotoxic. It is believed this is due to malfunctioning enzymes that have had replacements of Trp residues by 5-fluoro-Trp.1 However, at least one case is known where 5-fluoro-Trp substitution leads to significantly greater catalytic activity.2