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(24R)-24,25-Dihydroxyvitamin D3_分子结构_CAS_55721-11-4)
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(24R)-24,25-Dihydroxyvitamin D3

产品号 17943 公司名称 Sigma Aldrich
CAS号 55721-11-4 公司网站 http://www.sigmaaldrich.com
分子式 C27H44O3 电 话 1-800-521-8956
分子量 416.63646 传 真
纯 度 ≥98% (vitamin + pre-vitamin, HPLC) 电子邮件
保 存 Chembase数据库ID: 155996

产品价格信息

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产品别名

标题
(24R)-24,25-Dihydroxyvitamin D3
IUPAC标准名
(3R,6R)-6-[(1R,3aS,7aR)-4-{2-[(5S)-5-hydroxy-2-methylidenecyclohexylidene]ethylidene}-7a-methyl-octahydro-1H-inden-1-yl]-2-methylheptane-2,3-diol
IUPAC传统名
(3R,6R)-6-[(1R,3aS,7aR)-4-{2-[(5S)-5-hydroxy-2-methylidenecyclohexylidene]ethylidene}-7a-methyl-hexahydro-1H-inden-1-yl]-2-methylheptane-2,3-diol
别名
Secalciferol
(24R)-,24,25-Dihydroxycholecalciferol

产品登记号

CAS号 55721-11-4
Beilstein号 4567039
PubChem SID 24850812
MDL号 MFCD00941417

产品性质

Empirical Formula (Hill Notation) C27H44O3
纯度 ≥98% (vitamin + pre-vitamin, HPLC)
GHS危险品标识 GHS06
GHS警示词 Danger
GHS危险声明 H300
欧盟危险性物质标志 剧毒(Highly toxic) 剧毒(Highly toxic) (T+)
MSDS下载 下载链接
个人保护装置 Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS警示性声明 P264-P301 + P310
RID/ADR UN 2811 6.1/PG 2
危险公开号 28
RTECS编号 VS2895000
安全公开号 28-36/37-45
保存温度 -20°C
联合国危险货物等级 6.1
联合国危险货物编号 2811
联合国危险货物包装类别(PG) 2
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol) is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3. Other analogues of cholecalciferol result from different hydroxylations. 24R,25-Dihydroxyvitamin D3 is a catabolite of 25-Dihydroxyvitamin D3 and a putative regulator of developmental bone formation. 24R,25-Dihydroxyvitamin D3 is a substrate for renal 25-hydroxyvitamin D3 1 α-hydroxylase. 24R,25-Dihydroxyvitamin D3 is an endogenous regulator of apo A-I synthesis through a VDR-independent signaling mechanism and an inhibitor of Pi-induced apoptosis through Ca2+, PLD, and PLC signaling and through LPA-LPA1/3-G(αi)-PI(3)K-mdm2-mediated p53 degradation.
详细说明 (简体中文)
Biochem/physiol Actions
Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol) is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3. Other analogues of cholecalciferol result from different hydroxylations. 24R,25-Dihydroxyvitamin D3 is a catabolite of 25-Dihydroxyvitamin D3 and a putative regulator of developmental bone formation. 24R,25-Dihydroxyvitamin D3 is a substrate for renal 25-hydroxyvitamin D3 1 α-hydroxylase. 24R,25-Dihydroxyvitamin D3 is an endogenous regulator of apo A-I synthesis through a VDR-independent signaling mechanism and an inhibitor of Pi-induced apoptosis through Ca2+, PLD, and PLC signaling and through LPA-LPA1/3-G(αi)-PI(3)K-mdm2-mediated p53 degradation.

参考文献