1α-Hydroxyvitamin D3

• 产品号: 17946
• CAS号: 41294-56-8
• 分子式: C27H44O2
• 分子量: 400.63706
• 纯 度: ≥97.0% (HPLC)

产品别名

• 标题: 1α-Hydroxyvitamin D3
• IUPAC标准名: (1R,3S)-5-{2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol
• IUPAC传统名: (1R,3S)-5-{2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-hexahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol
• 别名: 1α-Hydroxycholecalciferol; Alfacalcidol

产品登记号

• PubChem SID: 24850815
• EC号: 255-297-1
• CAS号: 41294-56-8
• MDL号: MFCD00868328

产品性质

• Empirical Formula (Hill Notation): C27H44O2
• 纯度: ≥97.0% (HPLC)
• GHS警示词: Danger
• GHS危险声明: H300-H310-H330
• 欧盟危险性物质标志: 剧毒(Highly toxic) (T+)
• 个人保护装置: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS警示性声明: P260-P264-P280-P284-P302 + P350-P310
• RID/ADR: UN 2811 6.1/PG 1
• 危险公开号: 26/27/28
• RTECS编号: VS2851000
• 安全公开号: 28-36/37-45
• 保存温度: -20°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 1
• 德国WGK号: 3

产品详细信息

详细说明 (简体中文)

Biochem/physiol Actions
Synthetic vitamin D3 analog that is metabolized to 1,25-dihydroxycholecalciferol. Inhibits bone resorption and stimulates bone formation.1 Supresses parathyroid hormone secretion by bovine parathyroid cells.2
Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3 in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D3 has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D3 acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.

详细说明 (English)

Biochem/physiol Actions
Synthetic vitamin D3 analog that is metabolized to 1,25-dihydroxycholecalciferol. Inhibits bone resorption and stimulates bone formation.1 Supresses parathyroid hormone secretion by bovine parathyroid cells.2
Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3 in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D3 has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D3 acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.