4-Bromo-calcium Ionophore A23187

• 产品号: 16569
• CAS号: 76455-48-6
• 分子式: C29H36BrN3O6
• 分子量: 602.51664
• 纯 度: ≥95.0% (N)

产品别名

• 标题: 4-Bromo-calcium Ionophore A23187
• IUPAC标准名: 6-bromo-5-(methylamino)-2-{[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-2-yl]methyl}-1,3-benzoxazole-4-carboxylic acid
• IUPAC传统名: 6-bromo-5-(methylamino)-2-{[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-2-yl]methyl}-1,3-benzoxazole-4-carboxylic acid
• 别名: 4-Bromo-A23187; 4-Bromo-calcimycin

产品登记号

• PubChem SID: 24850144
• MDL号: MFCD00077667
• CAS号: 76455-48-6

产品性质

• Empirical Formula (Hill Notation): C29H36BrN3O6
• 纯度: ≥95.0% (N)
• 溶解度: ethanol: soluble20 mg/mL, clear, yellow
• GHS警示词: Warning
• GHS危险声明: H302-H312-H315-H319-H332-H335
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P280-P305 + P351 + P338
• 危险公开号: 20/21/22-36/37/38
• 安全公开号: 26-36/37
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
Nonfluorescent Ca2+ ionophore that can be used to calibrate the quantitation of cytoplasmic free Ca2+ with fluorescent probes.
Bromo-A23187, a nonfluorescent ionophore, has been used in photolysis of a caged-Ca2+ compound and in [Ca2+]i elevation protocols1. It can be used to calibrate the quantitation of cytoplasmic free Ca2+ with fluorescent probes.
Other Notes
In biological environment, bromo-A23187 has a higher selectivity for Ca2+ over Mg2+ than A231872
Biochem/physiol Actions
Ionophores disrupt transmembrane ion concentration gradients which are required for proper functioning and survival of microorganisms. An ionophore, such as Bromo-A23187, increases the permeability of biological membranes to calcium.

详细说明 (简体中文)

Application
Nonfluorescent Ca2+ ionophore that can be used to calibrate the quantitation of cytoplasmic free Ca2+ with fluorescent probes.
Bromo-A23187, a nonfluorescent ionophore, has been used in photolysis of a caged-Ca2+ compound and in [Ca2+]i elevation protocols1. It can be used to calibrate the quantitation of cytoplasmic free Ca2+ with fluorescent probes.
Other Notes
In biological environment, bromo-A23187 has a higher selectivity for Ca2+ over Mg2+ than A231872
Biochem/physiol Actions
Ionophores disrupt transmembrane ion concentration gradients which are required for proper functioning and survival of microorganisms. An ionophore, such as Bromo-A23187, increases the permeability of biological membranes to calcium.