Colistin sodium methanesulfonate

• 产品号: 27655
• CAS号: 8068-28-8
• 分子式: C58H115N16Na5O28S5
• 分子量: 1759.89795

产品别名

• 标题: Colistin sodium methanesulfonate
• IUPAC标准名: pentasodium N-[(1S)-3-amino-1-{[(1S,2R)-1-{[(1S)-3-amino-1-{[(3S,6S,9R,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl]carbamoyl}-2-hydroxypropyl]carbamoyl}propyl]-6-methyloctanamide pentamethanesulfonate
• IUPAC传统名: pentasodium N-[(1S)-3-amino-1-{[(1S,2R)-1-{[(1S)-3-amino-1-{[(3S,6S,9R,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl]carbamoyl}-2-hydroxypropyl]carbamoyl}propyl]-6-methyloctanamide pentamesylate
• 别名: Methanesulfonic acid derivative of Polymyxin E; Polymyxin E sodium methanesulfonate; Colimycin sodium methanesulfonate

产品登记号

• EC号: 232-516-9
• PubChem SID: 24856709
• CAS号: 8068-28-8
• MDL号: MFCD00130824

产品性质

• 生物来源: from Bacillus colistinus
• Empirical Formula (Hill Notation): C58H115N16Na5O28S5
• 燃烧残渣: ~20%
• 干燥失重: ≤1.5% loss on drying
• pH值: 6-8 (10 mg/mL in H2O)
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS编号: GH1650000
• 保存温度: 2-8°C
• 德国WGK号: 2

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.Antimicrobial spectrum: Gram-negative bacteria.
Colistin sodium methanesulfate is a cyclopolypeptide antibiotic with endotoxin-binding capacity3 Colistin′s activity stems from the hydrophobic and hydrophillic regions. They solubilze the cytoplasmic membrane which contributes to the bactericidal effect 4.
Other Notes
Cyclopolypeptide antibiotic. Endotoxin-binding capacity3
Application
Colistin sodium methanesulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination. It is used to study effective treatments of P. aeruginosa infections in cystic fibrosis patients 1 and to study the pharmacokinetics and BAL concentration of colistin in critically ill patients 2.

详细说明 (简体中文)

Biochem/physiol Actions
Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.Antimicrobial spectrum: Gram-negative bacteria.
Colistin sodium methanesulfate is a cyclopolypeptide antibiotic with endotoxin-binding capacity3 Colistin′s activity stems from the hydrophobic and hydrophillic regions. They solubilze the cytoplasmic membrane which contributes to the bactericidal effect 4.
Other Notes
Cyclopolypeptide antibiotic. Endotoxin-binding capacity3
Application
Colistin sodium methanesulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination. It is used to study effective treatments of P. aeruginosa infections in cystic fibrosis patients 1 and to study the pharmacokinetics and BAL concentration of colistin in critically ill patients 2.