Apigenin

• 产品号: 10798
• CAS号: 520-36-5
• 分子式: C15H10O5
• 分子量: 270.2369
• 纯 度: ≥95.0% (HPLC)

产品别名

• 标题: Apigenin
• IUPAC标准名: 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
• IUPAC传统名: chamomile
• 别名: 4′,5,7-Trihydroxyflavone

产品登记号

• EC号: 208-292-3
• CAS号: 520-36-5
• Beilstein号: 262620
• PubChem SID: 24846790
• MDL号: MFCD00006831

产品性质

• Empirical Formula (Hill Notation): C15H10O5
• 杂质: ~2% water
• 纯度: ≥95.0% (HPLC)
• 相关基因信息: human ... ADORA3(140), CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), ESR1(2099), ESR2(2100), GSK3A(2931)mouse ... Hexa(15211)rat ... Adora1(29290), Adora2a(25369), Il4(287287), Tnf(24835)
• 熔点: >300 °C(lit.)
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• RTECS编号: LK9276000
• 安全公开号: 26-36
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Other Notes
Inhibitor of human estrogen synthetase2
Biochem/physiol Actions
A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53.Inhibits PMA-mediated tumor promotion by inhibiting protein kinase C1 and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.

详细说明 (简体中文)

Other Notes
Inhibitor of human estrogen synthetase2
Biochem/physiol Actions
A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53.Inhibits PMA-mediated tumor promotion by inhibiting protein kinase C1 and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.