Item |
Information |
Drug Groups
|
experimental |
Description
|
A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids. [PubChem] |
Pharmacology |
Palmitic acid is the first fatty acid produced during lipogenesis (fatty acid synthesis) and from which longer fatty acids can be produced. Palmitate negatively feeds back on acetyl-CoA carboxylase (ACC) which is responsible for converting acetyl-ACP to malonyl-ACP on the growing acyl chain, thus preventing further palmitate generation |
Toxicity |
Acute oral toxicity (LD50) in rat is >10000 mg/kg |
External Links |
|
|