Biochem/physiol Actions Difloxacin inhibits bacterial DNA gyrase and the topoisomerase II enzyme, which inhibits DNA replication and transcription Fluoroquinolone antibacterial compound. Structurally related to norfloxacin. Pefloxacin is a synthetic fluoroquinolone that functions an antibacterial agent. It is an analog of norfloxacin. Mode of Action: A ds-DNA binding DNA gyrase inhibitor to dysrupt DNA synthesis. Use to study the metabolism of glycosaminoglycans and collagen in organ cultures of articular cartilage. Antimicrobial spectrum: Pefloxacin is highly active against Staphylococcus aureus, E. coli, other enterobacteria, and Pseudomonas aeruginosa.1 Active against gram-positive bacteria and excellent activity against gram-negative bacteria.2 Application Difloxacin is a fluoroquinolone antibiotic commonly used in veterinary medicine. It is a potential treatment for Chlamydia trachomatis infections1 and chronic Q fever in humans2. It has been used to study how potential supplementation (magnesium) may reduce quinolone-induced damage in the horse and dog models3. |