Pyr3

• 产品号: P0032
• 分子式: C16H11Cl3F3N3O3
• 分子量: 456.6310496
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Pyr3
• IUPAC标准名: ethyl 1-[4-(trichloroprop-2-enamido)phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
• IUPAC传统名: ethyl 1-[4-(trichloroprop-2-enamido)phenyl]-5-(trifluoromethyl)pyrazole-4-carboxylate
• 别名: Ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

产品登记号

• MDL号: MFCD00178741

产品性质

• Empirical Formula (Hill Notation): C16H11Cl3F3N3O3
• 纯度: ≥98% (HPLC)
• 外观: off-white powder
• 溶解度: DMSO: >20 mg/mL
• RID/ADR: UN 3077 9/PG 3
• 保存温度: 2-8°C
• 联合国危险货物等级: 9
• 联合国危险货物编号: 3077
• 联合国危险货物包装类别(PG): 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Pyr3 is a pyrazole compound that potently and selectively antagonizes TRPC3. Pyr3 inhibits TRPC3 by binding to the extracellular side of the receptor, resulting in suppression of B cell activation and cardiac hypertrophy.Members of the canonical transient receptor potential (TRPC) channel family are ion channels which conduct Ca+2 and are activated by membrane receptor-mediated stimulation of phospholipase C (PLC) activity. However, TRPC3 and other family members are also activated by membrane-independent diacylglycerol (DAG). BTP1 and BTP2 are pyrazoles that block TRPC channels, but they are not specific for TRPC subtypes. This channel is implicated in various processes, including B cell receptor (BCR)-mediated Ca+2 oscillations, activation of nuclear factor of activated T cells (NFAT), and promotion of cardiac hypertrophy.
Pyr3 is a selectively inhibitor of TRPC3. It acts by binding to the extracellular side of the receptor, resulting in suppression of B cell activation and cardiac hypertrophy.Members of the canonical transient receptor potential (TRPC) channel family are Ca2+ ion channels that are activated by membrane receptor-mediated stimulation of phospholipase C (PLC). However, TRPC3 and other family members are also activated by membrane-independent diacylglycerol (DAG). This channel is implicated in various processes, including B cell receptor (BCR)-mediated Ca2+ oscillations, activation of nuclear factor of activated T cells (NFAT), and promotion of cardiac hypertrophy.

详细说明 (简体中文)

Biochem/physiol Actions
Pyr3 is a pyrazole compound that potently and selectively antagonizes TRPC3. Pyr3 inhibits TRPC3 by binding to the extracellular side of the receptor, resulting in suppression of B cell activation and cardiac hypertrophy.Members of the canonical transient receptor potential (TRPC) channel family are ion channels which conduct Ca+2 and are activated by membrane receptor-mediated stimulation of phospholipase C (PLC) activity. However, TRPC3 and other family members are also activated by membrane-independent diacylglycerol (DAG). BTP1 and BTP2 are pyrazoles that block TRPC channels, but they are not specific for TRPC subtypes. This channel is implicated in various processes, including B cell receptor (BCR)-mediated Ca+2 oscillations, activation of nuclear factor of activated T cells (NFAT), and promotion of cardiac hypertrophy.
Pyr3 is a selectively inhibitor of TRPC3. It acts by binding to the extracellular side of the receptor, resulting in suppression of B cell activation and cardiac hypertrophy.Members of the canonical transient receptor potential (TRPC) channel family are Ca2+ ion channels that are activated by membrane receptor-mediated stimulation of phospholipase C (PLC). However, TRPC3 and other family members are also activated by membrane-independent diacylglycerol (DAG). This channel is implicated in various processes, including B cell receptor (BCR)-mediated Ca2+ oscillations, activation of nuclear factor of activated T cells (NFAT), and promotion of cardiac hypertrophy.