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Tranilast

产品号 T0318 公司名称 Sigma Aldrich
CAS号 53902-12-8 公司网站 http://www.sigmaaldrich.com
分子式 C18H17NO5 电 话 1-800-521-8956
分子量 327.33128 传 真
纯 度 ≥98% (HPLC) 电子邮件
保 存 Chembase数据库ID: 5256

产品价格信息

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产品别名

标题
Tranilast
IUPAC标准名
2-[3-(3,4-dimethoxyphenyl)prop-2-enamido]benzoic acid
IUPAC传统名
tranilast
别名
Rizaben
N-(3,4-Dimethoxycinnamoyl)anthranilic acid
SB-252218
3,4-DAA
2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino] benzoic acid

产品登记号

CAS号 53902-12-8
PubChem SID 24278719
MDL号 MFCD00864787

产品性质

Empirical Formula (Hill Notation) C18H17NO5
纯度 ≥98% (HPLC)
相关基因信息 human ... VEGFA(7422), VEGFB(7423), VEGFC(7424)
外观 white to beige powder
熔点 166.2-168.2 °C(lit.)
溶解度 DMSO: >10 mg/mL
溶解度 H2O: insoluble
GHS危险品标识 GHS07
GHS警示词 Warning
GHS危险声明 H302
欧盟危险性物质标志 有害性(Harmful) 有害性(Harmful) (Xn)
MSDS下载 下载链接
个人保护装置 dust mask type N95 (US), Eyeshields, Gloves
危险公开号 22
RTECS编号 DG8731000
安全公开号 26-36
保存温度 2-8°C
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
Tranilast is an anti-asthma drug, which inhibits LTC4 and PGE2 formation in stimulated monocytes, but does not inhibit cyclooxygenase or lipoxygenase activity; inhibits mast cell degranulation; inhibits VEGF-induced angiogenesis in vivo and also inhibits proliferation and tube formation of human endothelial cells in vitro. Tranilast may represent a new class of drugs for therapy to treat ongoing TH1-mediated autoimmune diseases.
详细说明 (简体中文)
Biochem/physiol Actions
Tranilast is an anti-asthma drug, which inhibits LTC4 and PGE2 formation in stimulated monocytes, but does not inhibit cyclooxygenase or lipoxygenase activity; inhibits mast cell degranulation; inhibits VEGF-induced angiogenesis in vivo and also inhibits proliferation and tube formation of human endothelial cells in vitro. Tranilast may represent a new class of drugs for therapy to treat ongoing TH1-mediated autoimmune diseases.

参考文献