Biochem/physiol Actions Allosteric agonist and antagonist of G-protein coupled receptors (GPCRs). General description Shown to modulate radioligand binding to various GPCRs including the human μ-, δ-, and κ-opiod, α- and β-adrenergic, muscarinic M1 and M2, and dopaminergic D1 and D2 receptors. Modulation is G-protein independent and is both selective and reversible. |
Biochem/physiol Actions Allosteric agonist and antagonist of G-protein coupled receptors (GPCRs). General description Shown to modulate radioligand binding to various GPCRs including the human μ-, δ-, and κ-opiod, α- and β-adrenergic, muscarinic M1 and M2, and dopaminergic D1 and D2 receptors. Modulation is G-protein independent and is both selective and reversible. |