N-(4-Acetamidophenyl)indomethacinamide

• 产品号: A1224
• 分子式: C27H24ClN3O4
• 分子量: 489.95016
• 纯 度: ≥98%

产品别名

• 标题: N-(4-Acetamidophenyl)indomethacinamide
• IUPAC标准名: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-(4-acetamidophenyl)acetamide
• IUPAC传统名: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-(4-acetamidophenyl)acetamide
• 别名: N-(4-Acetamidophenyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide; N-4AcetIA

产品登记号

• MDL号: MFCD02683236

产品性质

• Empirical Formula (Hill Notation): C27H24N3O4Cl
• 纯度: ≥98%
• 运输包装: wet ice
• 紫外吸收波长: λmax 267 nm
• 外观: crystalline
• 溶解度: DMSO: ≥15 mg/mL
• 溶解度: DMF: ≥23 mg/mL
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Potent and selective reversible COX-2 inhibitor. N-4-AcetIA inhibits human and ovine COX-2 with IC50 of 0.1 μM and 0.625 μM, respectively. About 400 times less potent as an inhibitor of human COX-1 and 80 times less potent as an inhibitor of ovine COX-1. Shows anti-inflammatory, antiangiogenic, and cancer chemopreventive activity in various experimental models.

详细说明 (简体中文)

Biochem/physiol Actions
Potent and selective reversible COX-2 inhibitor. N-4-AcetIA inhibits human and ovine COX-2 with IC50 of 0.1 μM and 0.625 μM, respectively. About 400 times less potent as an inhibitor of human COX-1 and 80 times less potent as an inhibitor of ovine COX-1. Shows anti-inflammatory, antiangiogenic, and cancer chemopreventive activity in various experimental models.