Alsterpaullone

• 产品号: A4847
• CAS号: 237430-03-4
• 分子式: C16H11N3O3
• 分子量: 293.27684
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: Alsterpaullone
• IUPAC标准名: 14-nitro-8,18-diazatetracyclo[9.7.0.0^2,^7.0^1^2,^1^7]octadeca-1(11),2,4,6,12,14,16-heptaen-9-one
• IUPAC传统名: alsterpaullone
• 别名: 9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-one

产品登记号

• MDL号: MFCD02683579
• PubChem SID: 24890918
• CAS号: 237430-03-4

产品性质

• Empirical Formula (Hill Notation): C16H11N3O3
• 纯度: ≥98% (HPLC)
• 相关基因信息: rat ... Gsk3b(84027)
• 外观: yellow to brown powder
• 溶解度: DMSO: ≥10 mg/mL
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• 安全公开号: 26-36
• 保存条件: desiccated
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Potent and selective inhibitor of GSK-3β and CDK5/p25; potent inhibitor of CDK1/cyclin B (IC50 = 0.035 μM).
Application
Alsterpaullone inhibits GSK-3β, CDK5/p25, and CDK1/cyclin B. Alsterpaullone has also been studied as an antimanic therapeutic for the acute manic phase of bipolar disorder.

详细说明 (简体中文)

Biochem/physiol Actions
Potent and selective inhibitor of GSK-3β and CDK5/p25; potent inhibitor of CDK1/cyclin B (IC50 = 0.035 μM).
Application
Alsterpaullone inhibits GSK-3β, CDK5/p25, and CDK1/cyclin B. Alsterpaullone has also been studied as an antimanic therapeutic for the acute manic phase of bipolar disorder.