Thio-TEPA

• 产品号: T6069
• CAS号: 52-24-4
• 分子式: C6H12N3PS
• 分子量: 189.218341
• 纯 度: 98%

产品别名

• 标题: Thio-TEPA
• IUPAC标准名: tris(aziridin-1-yl)-λ^5-phosphanethione
• IUPAC传统名: thiophosphamide
• 别名: Thio-Tep; Thiotef; N,N′,N″-Triethylenethiophosphoramide; Thiofozil; Tiofozil; Tio-tef; Tris(aziridinyl)phosphine sulfide; Tiofosyl; Tiofosfamid

产品登记号

• MDL号: MFCD00145452
• PubChem SID: 24900346
• CAS号: 52-24-4
• EC号: 200-135-7

产品性质

• 纯度: 98%
• Empirical Formula (Hill Notation): C6H12N3PS
• 外观: solid
• GHS警示词: Danger
• GHS危险声明: H300-H350
• 欧盟危险性物质标志: 剧毒(Highly toxic) (T+)
• 个人保护装置: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS警示性声明: P201-P264-P301 + P310-P308 + P313
• RID/ADR: UN 2811 6.1/PG 2
• 危险公开号: 45-46-28
• RTECS编号: SZ2975000
• 安全公开号: 53-22-26-36/37/39-45
• 保存温度: 2-8°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 2
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
Thio-TEPA (N,N’N’-triethylenethiophosphoramide) is used as a cancer chemotherapeutic, alkylating agent. It is used to treat various kinds of cancer such as breast, ovarian and bladder cancer. It is also used as conditioning treatment prior to haematopoietic progenitor cell transplantation (HPCT)1,2.
Biochem/physiol Actions
The unstable nitrogen-carbon groups alkylate with DNA which causes irreversible DNA damage. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. The DNA strands are unable to uncoil and separate which halts cell division1.

详细说明 (简体中文)

Application
Thio-TEPA (N,N’N’-triethylenethiophosphoramide) is used as a cancer chemotherapeutic, alkylating agent. It is used to treat various kinds of cancer such as breast, ovarian and bladder cancer. It is also used as conditioning treatment prior to haematopoietic progenitor cell transplantation (HPCT)1,2.
Biochem/physiol Actions
The unstable nitrogen-carbon groups alkylate with DNA which causes irreversible DNA damage. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. The DNA strands are unable to uncoil and separate which halts cell division1.