CGP-53353

• 产品号: C7866
• CAS号: 145915-60-2
• 分子式: C20H13F2N3O2
• 分子量: 365.3329264

产品别名

• 标题: CGP-53353
• IUPAC标准名: 5,6-bis[(4-fluorophenyl)amino]-2,3-dihydro-1H-isoindole-1,3-dione
• IUPAC传统名: 5,6-bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione
• 别名: DAPH 2; 5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione

产品登记号

• PubChem SID: 24892990
• CAS号: 145915-60-2
• MDL号: MFCD00938569

产品性质

• Empirical Formula (Hill Notation): C20H13F2N3O2
• 相关基因信息: human ... EGFR(1956)
• 外观: orange solid
• 溶解度: DMSO: >10 mg/mL
• 溶解度: H2O: insoluble
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Selective PKCβII inhibitor. IC50 - 410 nM for PKCβII vs 3.8 μM for PKCβI. Inhibits nPKCs and aPKCs only above 22 μM and other kinases such as protein kinase A, casein kinase I and II, c-src kinase, c-lyn kinase, c-fgr kinase, and v-abl kinase at an IC50 of greater than 50 μM.

详细说明 (简体中文)

Biochem/physiol Actions
Selective PKCβII inhibitor. IC50 - 410 nM for PKCβII vs 3.8 μM for PKCβI. Inhibits nPKCs and aPKCs only above 22 μM and other kinases such as protein kinase A, casein kinase I and II, c-src kinase, c-lyn kinase, c-fgr kinase, and v-abl kinase at an IC50 of greater than 50 μM.