Desmosine chloride

• 产品号: D9439
• CAS号: 10019-68-8
• 分子式: C24H40ClN5O8
• 分子量: 562.0561
• 纯 度: 99.5%±0.2%

产品别名

• 标题: Desmosine chloride
• IUPAC标准名: 3,5-bis(3-amino-3-carboxypropyl)-4-(4-amino-4-carboxybutyl)-1-(5-amino-5-carboxypentyl)pyridin-1-ium chloride
• IUPAC传统名: desmosine chloride

产品登记号

• MDL号: MFCD12910449
• CAS号: 10019-68-8

产品性质

• 生物来源: from bovine
• Empirical Formula (Hill Notation): C24H40ClN5O8
• 提纯方法: chromatography (and purified by solvent extraction)
• 纯度: 99.5%±0.2%
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Analysis Note
Calibrated by UV and amino acid analysis.
Application
Assays for free or urinary desmosine are often used as markers for disease states characterized by elastin degradation (e.g., emphysema).1 Conversely, excessive levels of incorporated desmosine are indicators of fibrotic conditions (e.g., cirrhosis).2
Desmosine chloride is often used in assays for free or urinary desmosine as markers for disease states characterized by elastin degradation (e.g., emphysema). Elastin degradation has shown strong correlation with vascular calcification, and pretreatment with aluminum ions can inhibit the binding of matrix metalloproteinase (MMP) to elastin.
Biochem/physiol Actions
Desmosine is a polyfunctional amino acid that forms cross-links in mature elastin.3
Caution
Extremely hygroscopic
General description
Each vial contains 1 μmole of purified desmosine.

详细说明 (简体中文)

Analysis Note
Calibrated by UV and amino acid analysis.
Application
Assays for free or urinary desmosine are often used as markers for disease states characterized by elastin degradation (e.g., emphysema).1 Conversely, excessive levels of incorporated desmosine are indicators of fibrotic conditions (e.g., cirrhosis).2
Desmosine chloride is often used in assays for free or urinary desmosine as markers for disease states characterized by elastin degradation (e.g., emphysema). Elastin degradation has shown strong correlation with vascular calcification, and pretreatment with aluminum ions can inhibit the binding of matrix metalloproteinase (MMP) to elastin.
Biochem/physiol Actions
Desmosine is a polyfunctional amino acid that forms cross-links in mature elastin.3
Caution
Extremely hygroscopic
General description
Each vial contains 1 μmole of purified desmosine.