节球毒素

• 产品号: N5148
• 分子式: C41H60N8O10
• 分子量: 824.9627

产品别名

• 标题: Nodularin
• IUPAC标准名: (5R,6S,9S,12S,13S,16R)-9-(3-carbamimidamidopropyl)-2-ethylidene-12-[(5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dien-1-yl]-1,6,13-trimethyl-3,7,10,14,19-pentaoxo-1,4,8,11,15-pentaazacyclononadecane-5,16-dicarboxylic acid
• IUPAC传统名: (5R,6S,9S,12S,13S,16R)-9-(3-carbamimidamidopropyl)-2-ethylidene-12-[(5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dien-1-yl]-1,6,13-trimethyl-3,7,10,14,19-pentaoxo-1,4,8,11,15-pentaazacyclononadecane-5,16-dicarboxylic acid
• 别名: 1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide

产品登记号

• MDL号: MFCD16659855

产品性质

• Empirical Formula (Hill Notation): C41H60N8O10
• 溶解度: methanol: soluble2 mg/mL (Further dilute to 10% (v/v) methanol. Store solutions at -20°C for up to six months.)
• GHS警示词: Danger
• GHS危险声明: H300 +H310 + H330-H315-H317-H319-H335
• 欧盟危险性物质标志: 剧毒(Highly toxic) (T+)
• GHS警示性声明: P260-P264-P280-P284-P301 + P310-P302 + P350
• RID/ADR: UN 2811 6.1/PG 2
• 危险公开号: 26/27/28-36/37/38-43
• RTECS编号: GU2294250
• 安全公开号: 26-36/37/39-45
• 保存温度: 2-8°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 2
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Potent inhibitor of protein phosphatases types 1 and 2A. Tumor promoter in experimental animal model.1; at higher doses, causes massive liver hemorrhage. Tumor-promoting effect is due to increasing oxidative stress, as evidenced by reduced levels of glutathione and appearance of oxidative damage in DNA bases.2

详细说明 (简体中文)

Biochem/physiol Actions
Potent inhibitor of protein phosphatases types 1 and 2A. Tumor promoter in experimental animal model.1; at higher doses, causes massive liver hemorrhage. Tumor-promoting effect is due to increasing oxidative stress, as evidenced by reduced levels of glutathione and appearance of oxidative damage in DNA bases.2