A1120

• 产品号: A3111
• 分子式: C20H19F3N2O3
• 分子量: 392.3716696
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: A1120
• IUPAC标准名: 2-({4-[2-(trifluoromethyl)phenyl]piperidine-1-carbonyl}amino)benzoic acid
• IUPAC传统名: 2-{4-[2-(trifluoromethyl)phenyl]piperidine-1-carbonylamino}benzoic acid
• 别名: 2-(4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid

产品登记号

• MDL号: MFCD12912393

产品性质

• Empirical Formula (Hill Notation): C20H19F3N2O3
• 纯度: ≥98% (HPLC)
• 外观: off-white powder
• 溶解度: DMSO: ≥10 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302-H317-H319-H400
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• GHS警示性声明: P273-P280-P305 + P351 + P338
• RID/ADR: UN 3077 9/PG 3
• 危险公开号: 22-36-43-50/53
• 安全公开号: 26-36/37-60-61
• 保存条件: desiccated
• 保存温度: 2-8°C
• 联合国危险货物等级: 9
• 联合国危险货物编号: 3077
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
A1120 is a selective non-retinoid ligand for retinol-binding protein 4 (RBP4). RBP4 transports retinol from the liver to extrahepatic tissues and RBP4 lowering is reported to improve insulin sensitivity in mice. A1120 is a high affinity non-retinoid ligand for RBP4 which disrupts the interaction between RBP4 and its binding partner transthyretin (TTR). It binds to the same site as retinol and induces changes in the orientation (compared to the retinol bound form) of loops at the RBP4-TTR interaction interface.A1120 lowers RBP4 and retinol levels in a dose-dependent manner, to a similar extent as seen with fenretinide. However, unlike fenretinide (Sigma# H7779), A1120 does not have beneficial effects on insulin resistance.

详细说明 (简体中文)

Biochem/physiol Actions
A1120 is a selective non-retinoid ligand for retinol-binding protein 4 (RBP4). RBP4 transports retinol from the liver to extrahepatic tissues and RBP4 lowering is reported to improve insulin sensitivity in mice. A1120 is a high affinity non-retinoid ligand for RBP4 which disrupts the interaction between RBP4 and its binding partner transthyretin (TTR). It binds to the same site as retinol and induces changes in the orientation (compared to the retinol bound form) of loops at the RBP4-TTR interaction interface.A1120 lowers RBP4 and retinol levels in a dose-dependent manner, to a similar extent as seen with fenretinide. However, unlike fenretinide (Sigma# H7779), A1120 does not have beneficial effects on insulin resistance.