Naltriben methanesulfonate hydrate

• 产品号: N156
• 分子式: C27H31NO8S
• 分子量: 529.60194
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Naltriben methanesulfonate hydrate
• IUPAC标准名: (1S,2S,13R,21R)-22-(cyclopropylmethyl)-11,14-dioxa-22-azaheptacyclo[13.9.1.0^1,^1^3.0^2,^2^1.0^4,^1^2.0^5,^1^0.0^1^9,^2^5]pentacosa-4(12),5,7,9,15,17,19(25)-heptaene-2,16-diol methanesulfonic acid hydrate
• IUPAC传统名: methanesulfonic acid naltriben hydrate
• 别名: NTB hydrate

产品登记号

• MDL号: MFCD11046015
• PubChem SID: 24278045

产品性质

• Empirical Formula (Hill Notation): C26H25NO4 · CH4O3S · xH2O
• 纯度: ≥98% (HPLC)
• 外观: off-white solid
• 溶解度: DMSO: soluble14 mg/mL at ~60 °C
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• RTECS编号: PB9175000
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Naltriben methanesulfonate is a highly selective δ2 opioid receptor antagonist. The relative ability of the delta antagonists benzylidenenaltrexone and naltriben to inhibit DPDPE-stimulated [35S]GTPgammaS binding suggests that the opioid receptor is of the delta-2 subtype. Ligand binding assays demonstrates biphasic binding of the antagonist to the single receptor type. [35S]GTPgammaS binding is also stimulated by [D-Ser2,Leu5,Thr6]enkepha

详细说明 (简体中文)

Biochem/physiol Actions
Naltriben methanesulfonate is a highly selective δ2 opioid receptor antagonist. The relative ability of the delta antagonists benzylidenenaltrexone and naltriben to inhibit DPDPE-stimulated [35S]GTPgammaS binding suggests that the opioid receptor is of the delta-2 subtype. Ligand binding assays demonstrates biphasic binding of the antagonist to the single receptor type. [35S]GTPgammaS binding is also stimulated by [D-Ser2,Leu5,Thr6]enkepha