12(S)-Hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid

• 产品号: H7768
• CAS号: 54397-83-0
• 分子式: C20H32O3
• 分子量: 320.46628
• 纯 度: ≥95% (HPLC)

产品别名

• 标题: 12(S)-Hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid
• IUPAC标准名: (12S)-12-hydroxyicosa-5,8,10,14-tetraenoic acid
• IUPAC传统名: (12S)-12-hydroxyicosa-5,8,10,14-tetraenoic acid
• 别名: (S)-12-HETE

产品登记号

• PubChem SID: 24895806
• Beilstein号: 2656104
• CAS号: 54397-83-0
• MDL号: MFCD00036916

产品性质

• 浓度: ~100 μg/mL in ethanol
• Empirical Formula (Hill Notation): C20H32O3
• 纯度: ≥95% (HPLC)
• 运输包装: dry ice
• 闪点: 14 °C
• 闪点: 57 °F
• 欧盟危险性物质标志: 易燃性(Flammable) (F)
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• RID/ADR: UN 1170 3/PG 2
• 危险公开号: 11-36/37/38
• 安全公开号: 7-16-26-36
• 保存温度: -20°C
• 联合国危险货物等级: 3
• 联合国危险货物编号: 1170
• 联合国危险货物包装类别(PG): 2
• 德国WGK号: 1

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Prometastatic metabolite of arachidonic acid via the 12-lipoxygenase pathway that is expressed in many tumor cell lines. It is produced in coronary microvasculature and is a potent inducer of relaxation and hyperpolarization of these microvessels. It activates large-conductance Ca2+-activated K+ currents in coronary microvascular smooth muscle.
12(S)-HETE is a bioactive lipid implicated in angiogenesis, growth, and metastasic action in tumor cell lines and in animal models. Arachidonate 12-lipoxygenase (12-LOX) converts arachidonic acid to 12(S)-(HETE). Alteration in 12-LOX expression or activity has been reported in various carcinomas including prostate carcinoma.
Packaging
Packaged under Argon.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. H7768.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

详细说明 (简体中文)

Biochem/physiol Actions
Prometastatic metabolite of arachidonic acid via the 12-lipoxygenase pathway that is expressed in many tumor cell lines. It is produced in coronary microvasculature and is a potent inducer of relaxation and hyperpolarization of these microvessels. It activates large-conductance Ca2+-activated K+ currents in coronary microvascular smooth muscle.
12(S)-HETE is a bioactive lipid implicated in angiogenesis, growth, and metastasic action in tumor cell lines and in animal models. Arachidonate 12-lipoxygenase (12-LOX) converts arachidonic acid to 12(S)-(HETE). Alteration in 12-LOX expression or activity has been reported in various carcinomas including prostate carcinoma.
包装
Packaged under Argon.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. H7768.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.