N-p-Tosyl-L-phenylalanine chloromethyl ketone

• 产品号: T4376
• CAS号: 402-71-1
• 分子式: C17H18ClNO3S
• 分子量: 351.84772
• 纯 度: ≥97% (TLC)

产品别名

• 标题: N-p-Tosyl-L-phenylalanine chloromethyl ketone
• IUPAC标准名: (2S)-4-chloro-S-(4-methylphenyl)-3-oxo-1-phenylbutane-2-sulfonamido
• IUPAC传统名: TPCK
• 别名: Tosyl-L-phenylalanyl-chloromethane; TPCK; (S)-1-Chloro-4-phenyl-3-tosylamido-2-butanone; (S)-1-Chloro-3-tosylamido-4-phenyl-2-butanone

产品登记号

• EC号: 206-954-6
• Beilstein号: 2895215
• PubChem SID: 24278737
• CAS号: 402-71-1
• MDL号: MFCD00000935

产品性质

• Empirical Formula (Hill Notation): C17H18ClNO3S
• 药效: 10-100 μM effective concentration
• 纯度: ≥97% (TLC)
• 相关基因信息: human ... NFKB1(4790), NKAP(79576), NKRF(55922), NOS2(4843), PTGS2(5743)
• 外观: white powder
• 熔点: 106-108 °C(lit.)
• 溶解度: DMSO: >10 mg/mL (stable for several months at 4°C.)
• 溶解度: ethanol: soluble20 mg/mL (stable for several months at 4°C. Stock solutions (10 mM in methanol or ethanol) are stable for several months at 4°C.)
• GHS警示词: Danger
• GHS危险声明: H315-H318-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P280-P305 + P351 + P338
• 危险公开号: 37/38-41
• RTECS编号: XT5613500
• 安全公开号: 26-36
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
Irreversible inhibitor of certain serine proteases; used to inhibit chymotrypsin in preparations of trypsin.
Caution
Shelf-life is at least two years when stored desiccated at -20 °C.
Biochem/physiol Actions
Blocks the LPS- or cytokine-induced activation of nuclear factor κB (NFκB), which, in turn, blocks the induction of iNOS and COX-2 transcription. Blocks activation of pp70s6k by all mitogens. Blocks apoptosis cell lines by inhibiting the processing of caspases in some cell lines and to some stimuli. Also blocks apoptosis initiated by Taxol (in MCF-7 human breast carcinoma cells).1

详细说明 (简体中文)

Application
Irreversible inhibitor of certain serine proteases; used to inhibit chymotrypsin in preparations of trypsin.
Caution
Shelf-life is at least two years when stored desiccated at -20 °C.
Biochem/physiol Actions
Blocks the LPS- or cytokine-induced activation of nuclear factor κB (NFκB), which, in turn, blocks the induction of iNOS and COX-2 transcription. Blocks activation of pp70s6k by all mitogens. Blocks apoptosis cell lines by inhibiting the processing of caspases in some cell lines and to some stimuli. Also blocks apoptosis initiated by Taxol (in MCF-7 human breast carcinoma cells).1