Nikkomycin Z from Streptomyces tendae

• 产品号: N8028
• CAS号: 59456-70-1
• 分子式: C20H25N5O10
• 分子量: 495.44
• 纯 度: ≥90% (HPLC)

产品别名

• 标题: Nikkomycin Z from Streptomyces tendae
• IUPAC标准名: (2R)-2-[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanamido]-2-[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]acetic acid
• IUPAC传统名: (R)-[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanamido][(2R,3S,4R,5R)-5-(2,4-dioxo-3H-pyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]acetic acid

产品登记号

• CAS号: 59456-70-1
• MDL号: MFCD00869648
• PubChem SID: 24897849

产品性质

• Empirical Formula (Hill Notation): C20H25N5O10
• 纯度: ≥90% (HPLC)
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• RTECS编号: BA2928200
• 安全公开号: 26-36
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
Nikkomycin Z is used as a selective competitive inhibitor of chitin synthetase 3 in studies on fungal cell wall development. It is a potential treatment for human Encephalitozoon hellem, a microsporidian species1 and is used to study the changes of chitin and β--glucan under Nikkomycin Z exposure2.
Biochem/physiol Actions
Nikkomycin Z inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine3. Nikkomycin Z has potent antifungal, insecticidal and acaridicial activity.

详细说明 (简体中文)

Application
Nikkomycin Z is used as a selective competitive inhibitor of chitin synthetase 3 in studies on fungal cell wall development. It is a potential treatment for human Encephalitozoon hellem, a microsporidian species1 and is used to study the changes of chitin and β--glucan under Nikkomycin Z exposure2.
Biochem/physiol Actions
Nikkomycin Z inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine3. Nikkomycin Z has potent antifungal, insecticidal and acaridicial activity.