Nafcillin sodium salt monohydrate

• 产品号: N3269
• CAS号: 7177-50-6
• 分子式: C21H23N2NaO6S
• 分子量: 454.47189

产品别名

• 标题: Nafcillin sodium salt monohydrate
• IUPAC标准名: sodium (2S,5R,6R)-6-(2-ethoxynaphthalene-1-amido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydrate
• IUPAC传统名: sodium nafcillin(1-) hydrate
• 别名: 6-(2-Ethoxy-1-naphthamido)penicillin

产品登记号

• PubChem SID: 24897636
• MDL号: MFCD01941128
• CAS号: 7177-50-6

产品性质

• 杂质: ~3.5% Sodium citrate
• 线性分子式: C21H21N2O5SNa · H2O
• GHS警示词: Danger
• GHS危险声明: H315-H317-H319-H334-H335
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS警示性声明: P261-P280-P305 + P351 + P338-P342 + P311
• 危险公开号: 36/37/38-42/43
• 安全公开号: 26-36
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
Nafcillin sodium is a narrow-spectrum β-lactam antibiotic. It is used to treat infections caused by Gram-positive bacteria, in particular, species of Staphylococci that are resistant to other penicillins. Nafcillin is used to study penicillin binding proteins (PBPs). It has been used to study penicillin-binding proteins 2a and heterogeneous expression of methicillin resistance in Staphylococcus aureus 1. It is a potential therapy of meningitis due to Staphylococcus aureus.2.
Biochem/physiol Actions
Nafcillin inhibits bacterial cell wall formation by inhibiting PBPs. The irreversible inhibition of the PBPs prevents the final crosslinking (transpeptidation) of the nascent peptidoglycan layer, which disrupts cell wall synthesis.

详细说明 (简体中文)

Application
Nafcillin sodium is a narrow-spectrum β-lactam antibiotic. It is used to treat infections caused by Gram-positive bacteria, in particular, species of Staphylococci that are resistant to other penicillins. Nafcillin is used to study penicillin binding proteins (PBPs). It has been used to study penicillin-binding proteins 2a and heterogeneous expression of methicillin resistance in Staphylococcus aureus 1. It is a potential therapy of meningitis due to Staphylococcus aureus.2.
Biochem/physiol Actions
Nafcillin inhibits bacterial cell wall formation by inhibiting PBPs. The irreversible inhibition of the PBPs prevents the final crosslinking (transpeptidation) of the nascent peptidoglycan layer, which disrupts cell wall synthesis.