DL-Propargylglycine

• 产品号: P7888
• CAS号: 64165-64-6
• 分子式: C5H7NO2
• 分子量: 113.11458

产品别名

• 标题: DL-Propargylglycine
• IUPAC标准名: 2-aminopent-4-ynoic acid
• IUPAC传统名: propargylglycine
• 别名: 2-Amino-4-pentynoic acid; PAG

产品登记号

• MDL号: MFCD00056728
• CAS号: 64165-64-6
• PubChem SID: 24898885

产品性质

• Empirical Formula (Hill Notation): C5H7NO2
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• 安全公开号: 26-36
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
DL-Propargylglycine (PAG) is an irreversible inhibitor of the enzyme cystathionine γ-lyase (GCL), a key enzyme involved in glutathione synthesis1 and the metabolic transsulfuration pathway which regulates homocysteine concentration and mediates cysteine synthesis.2 Treatment of animal disease models with PAG was shown to alleviate symptoms of diseases that impair the formation or action of hydrogen sulfide (H2S).3,4

详细说明 (简体中文)

Biochem/physiol Actions
DL-Propargylglycine (PAG) is an irreversible inhibitor of the enzyme cystathionine γ-lyase (GCL), a key enzyme involved in glutathione synthesis1 and the metabolic transsulfuration pathway which regulates homocysteine concentration and mediates cysteine synthesis.2 Treatment of animal disease models with PAG was shown to alleviate symptoms of diseases that impair the formation or action of hydrogen sulfide (H2S).3,4