土霉素 二水合物

• 产品号: O4636
• CAS号: 6153-64-6
• 分子式: C22H26N2O10
• 分子量: 478.44924
• 纯 度: ≥99% (TLC)

产品别名

• 标题: Oxytetracycline dihydrate
• IUPAC标准名: (4S,4aR,5S,5aR,6S,12aS)-4-(dimethylamino)-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrate
• IUPAC传统名: oxytetracycline hydrate

产品登记号

• MDL号: MFCD00151234
• PubChem SID: 24898000
• EC号: 201-212-8
• CAS号: 6153-64-6

产品性质

• 痕量阴离子: chloride (Cl-): ≤0.05%
• 痕量阴离子: sulfate (SO42-): ≤0.05%
• 痕量阳离子: Al: ≤0.001%
• 痕量阳离子: Ca: ≤0.2%
• 痕量阳离子: Cu: ≤0.0005%
• 痕量阳离子: Fe: ≤0.002%
• 痕量阳离子: K: ≤0.005%
• 痕量阳离子: Mg: ≤0.005%
• 痕量阳离子: Na: ≤0.01%
• 痕量阳离子: Pb: ≤0.001%
• 痕量阳离子: Zn: ≤0.0005%
• Empirical Formula (Hill Notation): C22H24N2O9 · 2H2O
• 燃烧残渣: ≤1.0%
• 杂质: ≤0.001% Phosphorus (P)
• 杂质: ≤0.1% Insoluble matter
• 产品线: BioXtra
• 纯度: ≥99% (TLC)
• 溶解度: 1 M HCl: soluble0.1 M, clear (yellow to yellow-orange)
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Antibiotic produced by Streptomyces rimosus.Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit.Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.Mode of Resistance: Active efflux, ribosome protection, tetracycline inactivation.
Oxytetracycline inhibits translation, which results in cell death. It binds to the 30S ribosomal subunit and prevents the amino-acyl Trna from binding to the A site of the ribosome. The binding is reversible in nature. Oxytetracycline is lipophilic so it can easily pass through a cell membrane and passively diffuses through channels in the bacterial membrane.
Application
Oxytetracycline is a tetracycline analog isolated from the actinomycete Streptomyces rimosus. Oxytetracycline is an antibiotic indicated for treatment of infections caused by Gram positive and Gram negative microorganisms such as Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae, and Diplococcus pneumoniae. It is used in studies on the oxytetracycline-resistance gene (otrA). It is used for fluorescence measurements of hepatocytes1.

详细说明 (简体中文)

Biochem/physiol Actions
Antibiotic produced by Streptomyces rimosus.Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit.Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.Mode of Resistance: Active efflux, ribosome protection, tetracycline inactivation.
Oxytetracycline inhibits translation, which results in cell death. It binds to the 30S ribosomal subunit and prevents the amino-acyl Trna from binding to the A site of the ribosome. The binding is reversible in nature. Oxytetracycline is lipophilic so it can easily pass through a cell membrane and passively diffuses through channels in the bacterial membrane.
Application
Oxytetracycline is a tetracycline analog isolated from the actinomycete Streptomyces rimosus. Oxytetracycline is an antibiotic indicated for treatment of infections caused by Gram positive and Gram negative microorganisms such as Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae, and Diplococcus pneumoniae. It is used in studies on the oxytetracycline-resistance gene (otrA). It is used for fluorescence measurements of hepatocytes1.