8-(4-Chlorophenylthio)-guanosine 3′,5′-cyclic monophosphate sodium salt

• 产品号: C5438
• CAS号: 51239-26-0
• 分子式: C16H14ClN5NaO7PS
• 分子量: 509.793191
• 纯 度: ~95% (HPLC)

产品别名

• 标题: 8-(4-Chlorophenylthio)-guanosine 3′,5′-cyclic monophosphate sodium salt
• IUPAC标准名: sodium (4aR,6R,7R,7aS)-6-{2-amino-8-[(4-chlorophenyl)sulfanyl]-6-oxo-6,9-dihydro-1H-purin-9-yl}-7-hydroxy-2-oxo-hexahydro-1,3,5,2λ^5-furo[3,2-d][1,3,2λ^5]dioxaphosphinin-2-olate
• IUPAC传统名: sodium (4aR,6R,7R,7aS)-6-{2-amino-8-[(4-chlorophenyl)sulfanyl]-6-oxo-1H-purin-9-yl}-7-hydroxy-2-oxo-tetrahydro-4H-1,3,5,2λ^5-furo[3,2-d][1,3,2λ^5]dioxaphosphinin-2-olate
• 别名: pCPT-cGMP; 8-pCPT-cGMP

产品登记号

• MDL号: MFCD00674888
• PubChem SID: 24892786
• CAS号: 51239-26-0

产品性质

• Empirical Formula (Hill Notation): C16H14ClN5NaO7PS
• 纯度: ~95% (HPLC)
• 外观: white powder
• 溶解度: H2O: soluble25 mg/mL
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Membrane-permeable analog of cGMP that does not affect cGMP-regulated phosphodiesterase. A more potent cGMP analog than 8-Br-cGMP due to greater membrane permeability and a higher resistance to hydrolysis by phosphodiesterase. Used as a selective activator of cGMP dependent protein kinase (PKG). Found to be a very potent cyclic nucleotide-gated channel agonist.

详细说明 (简体中文)

Biochem/physiol Actions
Membrane-permeable analog of cGMP that does not affect cGMP-regulated phosphodiesterase. A more potent cGMP analog than 8-Br-cGMP due to greater membrane permeability and a higher resistance to hydrolysis by phosphodiesterase. Used as a selective activator of cGMP dependent protein kinase (PKG). Found to be a very potent cyclic nucleotide-gated channel agonist.