Leflunomide

• 产品号: L5025
• CAS号: 75706-12-6
• 分子式: C12H9F3N2O2
• 分子量: 270.2072696

产品别名

• 标题: Leflunomide
• IUPAC标准名: 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
• IUPAC传统名: leflunomide
• 别名: 5-Methylisoxazole-4-(4-trifluoromethyl)carboxanilide

产品登记号

• CAS号: 75706-12-6
• PubChem SID: 24278516
• MDL号: MFCD00867593

产品性质

• Empirical Formula (Hill Notation): C12H9F3N2O2
• 相关基因信息: human ... DHODH(1723)
• GHS警示词: Danger
• GHS危险声明: H301-H315-H319-H335
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS警示性声明: P261-P301 + P310-P305 + P351 + P338
• RID/ADR: UN 2811 6.1/PG 3
• 危险公开号: 22-36/37/38
• RTECS编号: NY2354200
• 安全公开号: 26
• 保存温度: 2-8°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Immunosuppressive; inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is believed to inhibit dihydroorotate dehydrogenase (in the de novo pyrimidine synthesis pathway) as well as several protein tyrosine kinases.
Application
By virtue of its immunosuppressant effects, leflunomide has found use in organ transplantation1 and treatment of rheumatoid arthritis2 and other autoimmune diseases.

详细说明 (简体中文)

Biochem/physiol Actions
Immunosuppressive; inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is believed to inhibit dihydroorotate dehydrogenase (in the de novo pyrimidine synthesis pathway) as well as several protein tyrosine kinases.
Application
By virtue of its immunosuppressant effects, leflunomide has found use in organ transplantation1 and treatment of rheumatoid arthritis2 and other autoimmune diseases.