Ethambutol dihydrochloride

• 产品号: E4630
• CAS号: 1070-11-7
• 分子式: C10H26Cl2N2O2
• 分子量: 277.23164

产品别名

• 标题: Ethambutol dihydrochloride
• IUPAC标准名: (2R)-2-[(2-{[(2R)-1-hydroxybutan-2-yl]amino}ethyl)amino]butan-1-ol dihydrochloride
• IUPAC传统名: (2R)-2-[(2-{[(2R)-1-hydroxybutan-2-yl]amino}ethyl)amino]butan-1-ol dihydrochloride
• 别名: 2,2′-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride; Emb

产品登记号

• CAS号: 1070-11-7
• EC号: 213-970-7
• PubChem SID: 24894566
• MDL号: MFCD00216025

产品性质

• Empirical Formula (Hill Notation): C10H24N2O2 · 2HCl
• GHS警示词: Danger
• GHS危险声明: H360
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 个人保护装置: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS警示性声明: P201-P308 + P313
• 危险公开号: 61
• RTECS编号: EL3854000
• 安全公开号: 53-22-36/37/39-45
• 德国WGK号: 3

产品详细信息

详细说明 (简体中文)

Application
Ethambutol is an antimycobacterial used to treat tuberculosis in combination with other antibiotics to reduce the development of drug resistance. It has been used to study multidrug-resistant tuberculosis (MDR-TB) in highest-incidence-rate areas in China.1
Biochem/physiol Actions
Ethambutol is bacteriostatic against actively growing TB bacilli. Mycolic acids attach to the 5′-hydroxyl groups of D-arabinose residues of arabinogalactan and form mycolyl-arabinogalactan-peptidoglycan complex in the cell wall. Ethambutol disrupts arabinogalactan synthesis by inhibiting arabinosyltransferases, specifically those in Mycobacterium, interfering with the biosynthesis of arabinogalactans found in the cell wall of mycobacteria and leading to increased cell wall permeability.2,3

详细说明 (English)

Application
Ethambutol is an antimycobacterial used to treat tuberculosis in combination with other antibiotics to reduce the development of drug resistance. It has been used to study multidrug-resistant tuberculosis (MDR-TB) in highest-incidence-rate areas in China.1
Biochem/physiol Actions
Ethambutol is bacteriostatic against actively growing TB bacilli. Mycolic acids attach to the 5′-hydroxyl groups of D-arabinose residues of arabinogalactan and form mycolyl-arabinogalactan-peptidoglycan complex in the cell wall. Ethambutol disrupts arabinogalactan synthesis by inhibiting arabinosyltransferases, specifically those in Mycobacterium, interfering with the biosynthesis of arabinogalactans found in the cell wall of mycobacteria and leading to increased cell wall permeability.2,3