两性霉素 B 来源于链霉菌 属

• 产品号: A4888
• CAS号: 1397-89-3
• 分子式: C47H73NO17
• 分子量: 924.07902
• 纯 度: ~80% (HPLC)

产品别名

• 标题: Amphotericin B from Streptomyces sp.
• IUPAC标准名: (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,33R,35S,36R,37S)-33-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
• IUPAC传统名: amphotericin B
• 别名: Fungizone

产品登记号

• MDL号: MFCD00877763
• CAS号: 1397-89-3
• PubChem SID: 24890749
• EC号: 215-742-2
• Beilstein号: 78342

产品性质

• Empirical Formula (Hill Notation): C47H73NO17
• 纯度: ~80% (HPLC)
• 产品质量级别: PREMIUM
• 外观: powder
• 溶解度: DMF: soluble2-4 mg/mL
• 溶解度: DMSO: soluble30-40 mg/mL
• 溶解度: H2O: insoluble
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• RTECS编号: BU2625000
• 安全公开号: 26
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (简体中文)

Biochem/physiol Actions
Amphotericin B is a polyene antifungal antibiotic from Streptomyces. It has an affinity for sterols, primarily ergosterols, of fungal cell membranes. It forms channels in the membranes, causing small molecules to leak out which contributes to cell death. Antimicrobial spectrum: fungi and yeast.
Polyene antifungal antibiotic from Streptomyces. Affinity for sterols, primarily ergosterols, of fungal cell membranes. Forms channels in the membranes, causing small molecules to leak out. Antimicrobial spectrum: fungi and yeast.
Application
Amphotericin B is used to study the affects of the influx of calcium on antifungal activity, 1 and to study the binding and kinetics of Amphotericin B to sterols in monolayers, aqueous solutions, and phospholipid bilayers 2,3. It is also commonly used in tissue culture as an antifungal supplement.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

详细说明 (English)

Biochem/physiol Actions
Amphotericin B is a polyene antifungal antibiotic from Streptomyces. It has an affinity for sterols, primarily ergosterols, of fungal cell membranes. It forms channels in the membranes, causing small molecules to leak out which contributes to cell death. Antimicrobial spectrum: fungi and yeast.
Polyene antifungal antibiotic from Streptomyces. Affinity for sterols, primarily ergosterols, of fungal cell membranes. Forms channels in the membranes, causing small molecules to leak out. Antimicrobial spectrum: fungi and yeast.
Application
Amphotericin B is used to study the affects of the influx of calcium on antifungal activity, 1 and to study the binding and kinetics of Amphotericin B to sterols in monolayers, aqueous solutions, and phospholipid bilayers 2,3. It is also commonly used in tissue culture as an antifungal supplement.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information