Calpain Inhibitor I

• 产品号: A6185
• CAS号: 110044-82-1
• 分子式: C20H37N3O4
• 分子量: 383.52548
• 纯 度: ≥97% (TLC)

产品别名

• 标题: Calpain Inhibitor I
• IUPAC标准名: (2S)-2-[(2S)-2-acetamido-4-methylpentanamido]-4-methyl-N-[(2S)-1-oxohexan-2-yl]pentanamide
• IUPAC传统名: (2S)-2-[(2S)-2-acetamido-4-methylpentanamido]-4-methyl-N-[(2S)-1-oxohexan-2-yl]pentanamide
• 别名: MG-101; Ac-LLnL-CHO; N-Acetyl-L-leucyl-L-leucyl-L-norleucinal; ALLN; N-Acetyl-Leu-Leu-Norleu-al

产品登记号

• Beilstein号: 7656053
• CAS号: 110044-82-1
• MDL号: MFCD00065505
• PubChem SID: 24891066

产品性质

• Empirical Formula (Hill Notation): C20H37N3O4
• 纯度: ≥97% (TLC)
• 相关基因信息: human ... CAPN1(823), CTSB(1508), PSMA1(5682)
• 外观: white powder
• 溶解度: DMSO: soluble
• 溶解度: ethanol: soluble
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
Calpain inhibitor I reversibly blocks the calcium-dependent neutral cysteine protease calpain I. Calpains have been implicated in various cellular processes, including cell proliferation, apoptosis, and cell differentiation.
Biochem/physiol Actions
Can initiate apoptosis in HL-60 cells1 but blocks dexamethasone-induced apoptosis in thymocytes and cycloheximide-induced apoptosis in metamyelocytes.2 Inhibits cyclin B degradation and arrests the cell cycle at G1/S and at meta-/anaphase.3 Blocks induction of nitric oxide synthase by LPS in macrophages.4

详细说明 (简体中文)

Application
Calpain inhibitor I reversibly blocks the calcium-dependent neutral cysteine protease calpain I. Calpains have been implicated in various cellular processes, including cell proliferation, apoptosis, and cell differentiation.
Biochem/physiol Actions
Can initiate apoptosis in HL-60 cells1 but blocks dexamethasone-induced apoptosis in thymocytes and cycloheximide-induced apoptosis in metamyelocytes.2 Inhibits cyclin B degradation and arrests the cell cycle at G1/S and at meta-/anaphase.3 Blocks induction of nitric oxide synthase by LPS in macrophages.4